明胶/掺锶β-磷酸三钙/硫酸钙复合多孔支架的制备与性能

doi:10.11896/j.issn.1005-023X.2018.12.005

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Abstract The present work fabricated the calcium sulfate/strontium-doped β-tricalcium phosphate composite spherical pellets through the stirring spray drying method and using the calcium sulfate/strontium-doped β-TCP as raw material. Subsequently the composite spherical pellets were combined with gelatin, to get porous gelatin/calcium sulfate/strontium-doped β-tricalcium phosphate scaffolds. We employed X-ray diffraction (XRD),scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR), etc. to examine the products’ chemical composition, morphology and microstructure, and also investigated the degradability, porosity, mechanical properties and cytotoxicity. The results reveal that the composite porous scaffolds have an irregular pore structure with pore size ranging from 0.5 mm to 1.0 mm and the porosity of about (63±1.77)%, which could meet the requirements of scaffold for bone tissue engineering. Besides, the favorable compressive strength (average value (6.3±0.05) MPa) of the resul-tant scaffolds were observed. The cytotoxicity test showed that, the composite scaffolds exhibit no cytotoxic effect and good degradation rate and thereby can find potential application in bone tissue repair.

Key words： gelatin strontium-doped β-tricalcium phosphate calcium sulfate composite spheres porous scaffold

Published: 20 July 2018

CLC number:	TB321
	O649.4

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	Articles by authors
	QIN Xiaosu
	HUANG Jie
	LEI Yun
	YANG Zebin
	CHEN Qinghua
	YAN Tingting

Cite this article:

QIN Xiaosu,HUANG Jie,LEI Yun, et al. Fabrication and Properties of Porous Gelatin/Strontium-doped β-tricalcium Phosphate/Calcium Sulfate Scaffolds[J]. Materials Reports, 2018, 32(12): 1967-1972.

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http://www.mater-rep.com/EN/10.11896/j.issn.1005-023X.2018.12.005 OR http://www.mater-rep.com/EN/Y2018/V32/I12/1967

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