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| Synthesis and Drug Delivery Properties of Nano Metal-organic Framework ZIF-90 |
| Hong DONG,Xiaojun SUN,Xin ZHANG,Doudou YANG,Xueliang WANG,Fengming ZHANG
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| Key Laboratory of Green Chemical Engineering and Technology of College of Heilongjiang Province, College of Chemical and Environmental Engineering, Harbin University of Science and Technology, Harbin 150040 |
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Abstract Metal organic frameworks are a kind of porous crystalline material with periodic multidimensional network structure formed by metal ions and organic ligands self-assembly process, which have been applied widely in catalysis, sensing, storage of gas and medicine, etc. The ZIF-90 nanostructured material with particle sizes below 300 nm was prepared. The structure of the metal-organic framework was characterized by FTIR and XRD. Scanning electron microscopy (SEM) characterized the morphology and particle size. The results of loading and releasing anti-cancer drug 5-fluorouracil on ZIF-90 nano-drug carrier showed that the loading ability of the material was up to 1.245 g/g, and the release rate was over 95%. The stability of the drug carrier at different pH showed that the drug carrier could rapidly release the drug with the skeletal collapse in the acidic condition of the tumor cells, therefore, ZIF-90 has potential ability of the tumor to target the drug delivery.
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Published: 25 January 2018
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FTIR spectra of ZIF-90
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XRD diffraction spectrum of ZIF-90
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| Sample | Zn2+/g | ICA/g | Tertbutanol/mL | H2O/mL | ICA/Zn2+ | Productivity/% | Average particle diameter/nm | | 1 # | 0.092 8 | 0.12 | 10 | 10 | 4∶1 | 43.75 | 800±100 | | 2 # | 0.046 4 | 0.12 | 10 | 10 | 8∶1 | 31.25 | 1 000±200 | | 3 # | 0.037 2 | 0.12 | 10 | 10 | 10∶1 | 27.08 | 900±150 | | 4 # | 0.018 6 | 0.12 | 10 | 10 | 20∶1 | 22.92 | 550±50 | | 5 # | 0.012 4 | 0.12 | 10 | 10 | 30∶1 | 16.67 | 500±50 | | 6 # | 0.093 | 0.12 | 10 | 10 | 40∶1 | 10.50 | 400±50 | | 7 # | 0.075 | 0.12 | 10 | 10 | 50∶1 | 8.42 | 300±50 | | 8 # | 0.006 2 | 0.12 | 10 | 10 | 60∶1 | 6.25 | 250±50 |
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Effects of different ratios of ICA/Zn2+ on the synthesis of ZIF-90
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The SEM images of ZIF-90 with different ratio for ligand-to-metal iron
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Stability of ZIF-90 materials in different pH
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The N2 adsorption and desorption isotherms of ZIF-90
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UV-vis absorption spectra of 5-fluorouracil
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Standard curve of 5-fluorouracil
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The relationship between loading efficiency and time
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The relationship between drug release rate and time
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2018, Vol. 32 
