含辣素衍生结构单体及其聚合物的合成、抑菌与抑藻性能

doi:10.11896/j.issn.1005-023X.2018.02.007

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Abstract

Four compounds (4-hydroxy-2-methyl-5-methylthio benzyl acrylamide (A), 2-hydroxy-4-acrylamide methyl-5-methylthio-6-methyl benzyl acrylamide (B), 3-acrylamide methyl-2-hydroxy benzamide (C), 1-acrylamide methyl-2-naphthol (D)) containing capsaicin moieties were synthesized with substituted aromatic and N-methylol acrylamide by Friedel-Crafts alkylation reaction, and their structures were characterized by infrared spectroscopy (IR) and hydrogen nuclear magnetic spectra ( ¹H NMR). The results of antibacterial test showed that the best inhibitory activity can be observed on Staphylococcus aureus and Escherichia coli with compound D, reaching the minimum inhibitory concentration (MIC) of 0.187 5 mg/mL. Moreover, the inhibitory activity of D on the two tested algae performed the best. The resins synthesized with four compounds as functional monomers were verified to have great inhibitory activity on tested algae. Besides, the best inhibitory activity is obtained on resin comprised of compound D, which has the inhibition rate of over 50% after 72 h.

Key words： capsaicin derivatives resin synthesis antibacterial activity anti-alga capability

Published: 25 January 2018

CLC number:

O621.3

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	Articles by authors
	Xiaochun ZHANG
	Liangmin YU
	Xiaohui JIANG

Cite this article:

Xiaochun ZHANG,Liangmin YU,Xiaohui JIANG. Synthesis, Bacteriostatic and Anti-alga Capability of Monomers and Polymers Containing Capsaicin[J]. Materials Reports, 2018, 32(2): 193-197.

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http://www.mater-rep.com/EN/10.11896/j.issn.1005-023X.2018.02.007 OR http://www.mater-rep.com/EN/Y2018/V32/I2/193

Structures of target products

Synthesis of acrylic resin with different capsaicin derivative structure

IR and ¹H NMR of A

IR of the resins

MIC of tested compounds with two kinds of bacteria (unit:mg/mL)

Inhibitory effect of the tested compounds on Escherichia coli

Inhibitory effect of the tested compounds on Staphylococcus aureus

Effects of the subjects on the growth curve of the Phaeodactylum tricornutum Bohlin

Effects of the subjects on the growth curve of the Nitzschia closterium

Inhibitory rate of resin on algae(%)

Working curve of (a) the Phaeodactylum tricornutum Bohlin and (b) the Nitzschia closterium

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