内源性外泌体作为药物递释系统的研究进展<sup>*</sup>

doi:10.11896/j.issn.1005-023X.2017.013.022

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Abstract Exosomes are membrane vesicles secreted by living cells with size of 40—100 nm. Exosomes are very important natural messengers involving in cellular communication and substance transportation. As natural carriers for material transportation, exosomes have unique advantages including low toxicity, low immunogenicity and good permeability. So far, small molecular chemical drugs and genetic drugs have been successfully delivered by exosomes for treating tumor disease and Alzheimer′s disease. In this paper, a detailed review of exosomes used as drug delivery system is presented based on recent researches.

Key words： exosomes carriers drug delivery system tumor

Published: 04 May 2018

CLC number:

TB39

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	Articles by authors
	ZHAO Jialan
	WANG Yuemin
	NIU Yawei
	DONG Xiaoting
	QIN Linghao

Cite this article:

ZHAO Jialan,WANG Yuemin,NIU Yawei, et al. Research Progress of Exosomes Used as Drug Delivery System[J]. Materials Reports, 2017, 31(13): 160-165.

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http://www.mater-rep.com/EN/10.11896/j.issn.1005-023X.2017.013.022 OR http://www.mater-rep.com/EN/Y2017/V31/I13/160

1 Xitong D, Xiaorong Z. Targeted therapeutic delivery using engineered exosomes and its applications in cardiovascular diseases[J]. Gene,2016,575(2):377.
2 Kim M S, Haney M J, Zhao Y, et al. Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells[J]. Nanome-dicine: Nanotechnol, Biol Med,2016,12(3):655.
3 Record M, Subra C, Silvente-Poirot S, et al. Exosomes as intercellular signalosomes and pharmacological effectors[J]. Biochem Pharmacology,2011,81(10):1171.
4 Taverna S, Giallombardo M, Gil-Bazo I, et al. Exosomes isolation and characterization in serum is feasible in non-small cell lung cancer patients: Critical analysis of evidence and potential role in clinical practice[J]. Oncotarget,2016,7(19):28748.
5 Johnsen K B, Gudbergsson J M, Skov M N, et al. A comprehensive overview of exosomes as drug delivery vehicles-endogenous nanocarriers for targeted cancer therapy[J]. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer,2014,1846(1):75.
6 Nishida-Aoki N, Ochiya T. Interactions between cancer cells and normal cells via miRNAs in extracellular vesicles[J]. Cellular Molecular Life Sci,2015,72(10):1849.
7 Milane L, Singh A, Mattheolabakis G, et al. Exosome mediated communication within the tumor microenvironment[J]. J Controlled Release,2015,219:278.
8 Vlassov A V, Magdaleno S, Setterquist R, et al. Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials[J]. Biochim Et Biophys Acta,2012,1820(7):940.
9 Tran T H, Mattheolabakis G, Aldawsari H, et al. Exosomes as nanocarriers for immunotherapy of cancer and inflammatory diseases[J]. Clinical Immunology,2015, 160(1):46.
10 Kawikova I, Askenase P W. Diagnostic and therapeutic potentials of exosomes in CNS diseases[J]. Brain Res,2015,1617:63.
11 Batrakova E V, Kim M S. Using exosomes, naturally-equipped nanocarriers, for drug delivery[J]. J Controlled Release,2015,219:396.
12 Yamashita T, Takahashi Y, Nishikawa M, et al. Effect of exosome isolation methods on physicochemical properties of exosomes and clearance of exosomes from the blood circulation[J]. Eur J Pharmaceutics Biopharmaceutics,2016,98:1.
13 Johnsen K B, Gudbergsson J M, Skov M N, et al. Evaluation of electroporation-induced adverse effects on adipose-derived stem cell exosomes[J]. Cytotechnology,2016,8:1.
14 Ban J J, Lee M, Im W, et al. Low pH increases the yield of exosome isolation[J]. Biochem Biophys Res Commun,2015,461(1):76.
15 Sunkara V, Woo H K, Cho Y K. Emerging techniques in the isolation and characterization of extracellular vesicles and their roles in cancer diagnostics and prognostics[J]. Analyst, 2016,141(2):371.
16 Hannafon B N, Ding W Q. Intercellular communication by exosome-derived microRNAs in cancer[J]. Int J Molecular Sci,2013,14(7):14240.
17 Hazan-Halevy I, Rosenblum D, Weinstein S, et al. Cell-specific uptake of mantle cell lymphoma-derived exosomes by malignant and non-malignant B-lymphocytes[J]. Cancer Lett, 2015,364(1):59.
18 Toda Y, Takata K, Nakagawa Y, et al. Effective internalization of U251-MG-secreted exosomes into cancer cells and characterization of their lipid components[J]. Biochem Biophys Res Commun,2015,456(3):768.
19 Takahashi Y, Nishikawa M, Shinotsuka H, et al. Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection[J].J Biotechnol,2013,165(2):77.
20 Smyth T, Kullberg M, Malik N, et al. Biodistribution and delivery efficiency of unmodified tumor-derived exosomes[J]. J Controlled Release,2015,199:145.
21 Fuhrmann G, Serio A, Mazo M, et al. Active loading into extracellular vesicles significantly improves the cellular uptake and photodynamic effect of porphyrins[J]. J Controlled Release,2015,205:35.
22 Haney M J, Klyachko N L, Zhao Y, et al. Exosomes as drug deli-very vehicles for Parkinson′s disease therapy[J]. J Controlled Release,2015,207:18.
23 Kooijmans S A A, Stremersch S, Braeckmans K, et al. Electroporation-induced siRNA precipitation obscures the efficiency of siRNA loading into extracellular vesicles[J]. J Controlled Release,2013,172(1):229.
24 Lamichhane T N, Raiker R S, Jay S M. Exogenous DNA loading into extracellular vesicles via electroporation is size-dependent and enables limited gene delivery[J]. Molecular Pharmaceutics,2015,12(10):3650.
25 Wahlgren J, Karlson T D L, Brisslert M, et al. Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes[J]. Nucleic Acids Res,2012, 40(17):610.
26 Shtam T A, Kovalev R A, Varfolomeeva E Y, et al. Exosomes are natural carriers of exogenous siRNA to human cells in vitro[J]. Cell Communication Signaling,2013,11(1):1.
27 Pascucci L, Coccè V, Bonomi A, et al. Paclitaxel is incorporated by mesenchymal stromal cells and released in exosomes that inhibit in vitro tumor growth: A new approach for drug delivery[J]. J Controlled Release,2014,192:262.
28 Munoz J L, Bliss S A, Greco S J, et al. Delivery of functional anti-miR-9 by mesenchymal stem cell-derived exosomes to glioblastoma multiforme cells conferred chemosensitivity[J]. Molecular Therapy—Nucleic Acids,2013,2(10):e126.
29 Katakowski M, Buller B, Zheng X, et al. Exosomes from marrow stromal cells expressing miR-146b inhibit glioma growth[J]. Cancer Lett,2013,335(1):201.
30 Zhao Y, Haney M J, Gupta R, et al. GDNF-Transfected macrophages produce potent neuroprotective effects in parkinson′s disease mouse model[J]. Plos One,2014,9(9):e106867.
31 Alhasan A H, Patel P C, Choi C H J, et al. Exosome encased spherical nucleic acid gold nanoparticle conjugates as potent microRNA regulation agents[J]. Small,2014,10(1):186.
32 Alvarez-Erviti L, Seow Y, Yin H F, et al. Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes[J]. Nat Biotechnol,2011,29(4):341.
33 Lee J, Lee H, Goh U, et al. Cellular engineering with membrane fusogenic liposomes to produce functionalized extracellular vesicles[J]. ACS Appl Mater Interfaces,2016,8(11):6790.
34 Kooijmans S A, Fliervoet L A, Van d M R, et al. PEGylated and targeted extracellular vesicles display enhanced cell specificity and circulation time[J]. J Controlled Release,2016, 224:77.
35 Qi H, Liu C, Long L, et al. Blood exosomes endowed with magnetic and targeting properties for cancer therapy[J]. ACS Nano,2016,10(3):3323.
36 Tian Y, Li S, Song J, et al. A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy[J]. Biomaterials,2014,35(7):2383.
37 Toffoli G, Hadla M, Corona G, et al. Exosomal doxorubicin reduces the cardiac toxicity of doxorubicin[J]. Nanomedicine,2015,10(19):2963.
38 Saari H, Lázaro-Ibáñez E, Viitala T, et al. Microvesicle-and exosome-mediated drug delivery enhances the cytotoxicity of Paclitaxel in autologous prostate cancer cells[J]. J Controlled Release,2015,220:727.
39 Sun D, Zhuang X, Xiang X, et al. A novel nanoparticle drug deli-very system: The anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes[J]. Molecular Therapy,2010,18(9):1606.
40 Zhuang X, Xiang X, Grizzle W, et al. Treatment of brain inflammatory diseases by delivering exosome encapsulated anti-inflammatory drugs from the nasal region to the brain[J]. Molecular Therapy,2011,19(10):1769.
41 Ohno S, Takanashi M, Sudo K, et al. Systemically injected exosomes targeted to EGFR deliver antitumor microRNA to breast can-cer cells[J]. Molecular Therapy,2013,21(1):185.
42 Cooper J M, Wiklander P B, Nordin J Z, et al. Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice[J]. Movement Disorders, 2014,29(12):1476.
43 Xin H, Li Y, Cui Y, et al. Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats[J]. J Cerebral Blood Flow Metabolism,2013,33(11):1711.
44 Bonafede R, Scambi I, Peroni D, et al. Exosome derived from murine adipose-derived stromal cells: Neuroprotective effect onin vitromodel of amyotrophic lateral sclerosis[J]. Experimental Cell Res,2015,340(1):150.
45 Pusic A D, Pusic K M, Clayton B L L, et al. IFNγ-stimulated dendritic cell exosomes as a potential therapeutic for remyelination[J]. J Neuroimmunology,2014,266(1):12.
46 Nojima H, Freeman C M, Schuster R M, et al. Hepatocyte exosomes mediate liver repair and regeneration via sphingosine-1-phosphate[J]. J Hepatology,2016,64(1):60.
47 Choi J S, Yoon H I, Lee K S, et al. Exosomes from differentiating human skeletal muscle cells trigger myogenesis of stem cells and provide biochemical cues for skeletal muscle regeneration[J]. J Controlled Release,2015,222:107.
48 Li K, Chang S, Wang Z, et al. A novel micro-emulsion and micelle assembling method to prepare DEC205 monoclonal antibody coupled cationic nanoliposomes for simulating exosomes to target dendritic cells[J]. Int J Pharmaceutics,2015,491(1):105.
49 Jang S C, Kim O Y, Yoon C M, et al. Bioinspired exosome-mimetic nanovesicles for targeted delivery of chemotherapeutics to malignant tumors[J]. ACS Nano,2013,7(9):7698.
50 Jo W, Kim J, Yoon J, et al. Large-scale generation of cell-derived nanovesicles[J]. Nanoscale,2014,6(20):12056.
51 Yin W, Ouyang S, Li Y, et al. Immature dendritic cell-derived exosomes: A promise subcellular vaccine for autoimmunity[J]. Inflammation,2013,36(1):232.
52 Yeo R W Y, Lai R C, Zhang B, et al. Mesenchymal stem cell: An efficient mass producer of exosomes for drug delivery[J]. Adv Drug Delivery Rev,2013,65(3):336.
53 Lai R C, Yeo R W Y, Tan K H, et al. Exosomes for drug delive-ry—A novel application for the mesenchymal stem cell[J]. Biotech-nol Adv,2013,31(5):543.