基于中性粒细胞的分子影像探针研究进展

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Abstract Neutrophils are the most abundant circulating leukocytes and the first line of defense against invading pathogens, and are the key component of the innate immune system. However, neutrophils also cause tissue damage in various autoimmune and inflammatory diseases and play an important role in cancer progression. Due to the complex relationship between various diseases and neutrophils, neutrophils have become an exciting target for therapeutic intervention. Molecular imaging refers to the quantitative, non-invasive and repetitive imaging of biological molecules in vivo, and monitoring the related biological processes of living organisms. This review will focus on two aspects: drug delivery with neutrophils as carrier and designing specific probes to target neutrophils.

Key words： neutrophils molecular imaging inflammation cancer nanoparticles probe

Published: 16 July 2021

CLC number:	R318.08
	R314

Fund:Wu Jieping Medical Foundation (320.6750).

About author:: Manman Li formerly working in the Department of Imaging, Yancheng First People's Hospital, attending physician, is now a first-year graduate student majoring in imaging medicine and nuclear medicine, School of Medicine, Nantong University.Molecular imaging research was carried out under the guidance of Professor Feng Feng.Feng Feng graduated from Nanjing Medical University in 2000 and graduated from Fudan University in 2013. He is the director, chief physician and master's supervisor of the Imaging Department of the Cancer Hospital affiliated to Nantong University. Chinese Medical Association Radiology Association Infection Imaging National Youth Committee, National Committee member of tumor Imaging Committee of China Anti-Cancer Association, member of Magnetic Resonance Group of Jiangsu Ra-diology Association, member of Respiratory Group of Jiangsu Medical Asso-ciation Radiology Association, Nantong 226 third-level talents, vice chairman of Nantong Medical Association Radiology Association, chairman of tumor imaging major of Nantong Anti-Cancer Association. The research direction is the imaging diagnosis of chest diseases, with emphasis on the diagnosis and differential diagnosis of lung cancer, as well as molecular imaging research. He has published more than 40 papers as the first author and corresponding author, more than 20 core journals, and participated in 4 monographs.

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Cite this article:

LI Manman,FENG Feng. Research Progress of Molecular Imaging Probes Based on Neutrophils[J]. Materials Reports, 2021, 35(Z1): 507-512.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2021/V35/IZ1/507

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