Materials Reports  2021, Vol. 35 Issue (Z1): 513-517 |
| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Preparation and Characterization of Multi-response Nanogels by Reflux Precipitation Polymerization |
| SHEN Yulin1,2, LI Ting1,2, YE Chaoyu1,2, WANG Xiaomei1,2, LYU Yi1,2, PAN Zaifan1,2, WANG Zhao1,2
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1 School of Materials Engineering, Jinling Institute of Technology, Nanjing 211106,China
2 Nanjing Key Laboratory of Optometric Materials and Technology, Nanjing 211106,China |
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Abstract P(MAA-co-NIPAM) nanogels with multi-responsiveness were prepared by Reflux Precipitation Polymerization using methacrylic acid (MAA) and N-isopropylacrylamide (NIPAM) as monomers. The size and morphology of the nanogels were characterized by dynamic light scatte-ring (DLS) and transmission electron microscopy (TEM), and their multiple stimulus responsiveness, drug loading behavior and cytotoxicity were further studied. Results indicate that monodisperse nanogels with different particle sizes were obtained by adjusting the feeding ratio. The nanogels showed good thermo, pH and reduction responsiveness, as well as high DOX loading efficiency and good cytocompatibility, beneficial for using as smart drug delivery carriers.
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Published: 16 July 2021
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| Fund:Natural Science Foundation of Jiangsu province (BK20190113) and Innovation and Entrepreneurship Training Program for College Students of Jiangsu Province (202013573066Y). |
| About author:: Yulin Shen studies at School of Materials Engineering, Jinling Institute of Technology from 2018. Her research interest is synthesis and characterization of biomedical materials.Zhao Wang received her Ph.D. degree in polymer chemistry and physics from the Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, in 2016. After two-year postdoctoral research at department of polymer science, Fudan University, she joined School of Materials Engineering, Jinling University of Technology in 2018. Her research interests are design and preparation of polymeric drug delivery systems. She has published more than 10 journal papers as the first author, won third prize of Science and Technology Award of Jiangsu Pro-vince, and now in charge of natural science foundation of Jiangsu Province. |
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