超临界二氧化碳辅助制备β-环糊精-药物包合物的研究进展

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Abstract Due to its good biocompatibility and biodegradability, β-cyclodextrin is widely used in the fields of the drug, medicine and environment and so on. In this paper, the basic properties of β-cyclodextrin and its application in pharmaceutical fields were described, and the characteristics of supercritical fluid as a green solvent and its application in pharmaceutical preparations were briefly discussed. Some research methods and results on β-cyclodextrin inclusion complex prepared by supercritical carbon dioxide were introduced. Finally, the development direction on the application of β-cyclodextrin and the research of supercritical fluid were prospected.

Key words： β-cyclodextrin supercritical carbon dioxide β-cyclodextrin inclusion complex drug microparticles

Published: 25 November 2019

CLC number:

TB34

Fund:This work was financially supported by the National Natural Science Foundation of China (21676038).

About author:: Jingchang Wang is a professor and postgraduate supervisor at college of environmental and chemical enginee-ring of Dalian University. He has published more than 20 research papers in the academic journals at home and abroad as the first author, and applied 7 national invention patents, 5 of them were authorized. Her research direction is the research on the functional polymer materials.
Shiping Zhan is a professor and doctoral supervisor at college of environmental and chemical engineering of Dalian University. At the same time, she is also a leader of the functional polymer material team. She has published more than 50 research papers in the academic journals at home and abroad and authorized 18 national invention patents were obtained. In recent years, her research interests are the field of the polymer microparticles preparation by supercritical fluid technology, drug release performance of the targeted polymer drug-loaded microparticles, pre-paration of the biomedical polymer materials, etc.

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	WANG Jingchang
	ZHAO Yu
	MIAO Hongyu
	ZHAO Qicheng
	ZHAN Shiping

Cite this article:

WANG Jingchang,ZHAO Yu,MIAO Hongyu, et al. Preparation of β-cyclodextrin-drug Inclusion Complex Aided by SupercriticalCarbon Dioxide[J]. Materials Reports, 2019, 33(Z2): 542-546.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2019/V33/IZ2/542

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