Materials Reports  2020, Vol. 34 Issue (Z2): 142-146 |
| INORGANIC MATERIALS AND CERAMIC MATRIX COMPOSITES |
|
|
|
|
|
| Investigation of the Bioactive Glass on Wound Repair After Mineralization in Vitro for Different Time |
| HU Fang1, WANG Jian1, QIU Yuexiu1,2, GUO Chuangzhou1, LIU Mingdong1
|
1 Beijing Best Life Regenerative Medicine Technology Co., Ltd., Beijing 101200, China
2 Central Iron and Steel Research Institute, Beijing 100081, China |
|
|
|
|
Abstract This work takes a new type of biomedical material—bioactive glass as the main research object. The bioactive glass was mineralized in vitro for different time. Nitrogen adsorption, SEM and X-ray diffraction were employed to characterize the specific surface area, microstructure and phase before and after mineralization of the bioactive glass. Through the in vitro mineralization test, and the establishment of Guizhou pig skin wound surface model, the wound healing time and the healing rate were counted, as well as the HE staining analysis was performed to explore the difference in the bioactive glass on wound repair after in vitro mineralization for different time. Studies showed that the original specific surface area of bioactive glass was 186.8 m2/g, and regular three-dimensional network structure of carbonated hydroxyapatite was formed after 24 hours of immersion in simulated body fluids, and its specific surface area was up to 250.45 m2/g; the specific surface area of three-dimensional network structure treated for 48 hours was 472.30 m2/g, 2.5 times that of untreated materials. The original bioactive glass caused the wound surface of 5 cm×5 cm×4 cm to fill the whole wound surface with new tissue on (19.33±0.37) days, the repair of the wound surface required (22.16±0.65)days and (25.5±0.25)days with 24 hours and 48 hours of mineralization,. The bioactive glass group without mineralization could significantly promote wound healing, and the difference was statistically significant (P<0.05). Histological analysis showed that bioactive glass without mineralization could reduce inflammatory response, promote rapid and orderly growth of fibroblasts and capillaries, and complete new tissue structure.
|
|
Published: 08 January 2021
|
|
|
| About author:: Fang Hu, general manager of the Beijing Bestlife Regenerative Medicine Technology Co., Ltd., as investigators and core of scientific research personnel for biological activity of inorganic non-metallic materials research, applied for more than 40 invention patents and 7 international patents.Jian Wang, researcher of Beijing Bestlife Regenerative Medicine Technology Co., Ltd., graduated from the School of Materials Science and Engineering, Nanchang Hangkong University from September 2012 to December 2014. His research interests focus on the medical materials and devices made of inorganic non-metallic mate-rials. Published one paper and applied for 12 national invention patents, which 5 were authorized. Participated in a number of national science and technology projects, including the National Key Research and Development Plan During the 13th Five-year Plan Period and the National Natural Science Foundation. |
|
|
1 李晓琴, 但卫华, 王康建,等,材料导报, 2010, 23(z1),374.
2 Zhao S C, Li L, Wang H, et al.Biomat Erials, 2015, 53, 379.
3 付小兵.中华烧伤杂志,2016, 32(1), 6.
4 方少霞, 郭芬.中国组织工程研究,2016, 20(23), 3491.
5 赵娜如,王迎军,陈晓峰,等.材料导报, 2004, 18(12), 78.
6 杨维虎, 左奕, 张利, 等.无机化学学报, 2009, 25(2), 223.
7 郭明锋, 马杰, 蔡卫林, 等.中华创伤杂志, 2014, 30(1), 85.
8 陈梦越, 李乐之.中华护理杂志, 2016, 51(12), 1483.
9 冯志凯,刘华.中华外科杂志, 2012, 50(4), 368.
10 Yu H F, Peng J L, Xu Y H, et al.ACS Applied Materials & Interfaces, 2016, 8, 703.
11 Ye Y L, Wang S H, Sun J M, et al. Clinical Medicine, 2007, 27(7), 48.
12 廖建贵.小肠粘膜下层冷冻凝胶用于细胞移植支架的研究.硕士学位论文.第三军医大学, 2016.
13 燕晓宇,杨光,成亮,等.中国组织工程研究, 2012, 16(15), 2745. |
|
|
|
渝公网安备50019002502923号 © Editorial Office of Materials Reports.
