含钙铁氧体磁性生物活性玻璃陶瓷热种子的制备与表征

doi:10.11896/j.issn.1005-023X.2018.24.001

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Abstract In present research, magnetic bioactive glass ceramic thermoseed containing Ca ferrite was prepared using the bioa-ctive glass ceramic precursor synthesized by sol-gel method and Ca ferrite. Experiments were carried out to evaluate the crystalline composition, magnetic property, heat generating ability under alternative magnetic field, as well as the lethal effect of the magnetically induced heat to cells, bioactivity in vitro and tissue biocompability in vivo. The results revealed that the main crystal of the material was CaSiO₃, Ca₅(PO₄)₃F and CaFe₂O₄. Under a magnetic field about 8×10⁵ A·m^-1, the saturation magnetization and coercive force of the composite were about 5 A·m²·kg^-1 and 2×10⁴ A·m^-1, respectively. When exposed to an alternative magnetic field with the frequency of 342 kHz and the magnitude of 1×10³ A/m, the material can realize a temperature rise of 40 ℃ in 20 min. After soaking in simulated body fluid for 14 d, a non-continuous biological active layer containing carbonate could be observed on the material surface. The MTT assay revealed that the material had no cytotoxicity. MG 63 cells could adhere and grow on the material. Moreover, the experiment of material and cell co-culturing under alternative magnetic filed showed that a circle of dead cell appeared around the material. The results of rabbit muscle implantation showed that the material had good tissue biocompatibility in vivo.

Key words： magnetic bioactive glass ceramics thermoseeds Ca ferrite magnetically induced hyperthermia

Published: 23 January 2019

CLC number:

R318

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	Articles by authors
	LI Guangda
	ZHANG Nan
	ZHANG Kaili
	ZHAO Santuan
	MA Kaiwang
	XU Helong
	ZHAO Wei
	XIE Huixu

Cite this article:

LI Guangda,ZHANG Nan,ZHANG Kaili, et al. Synthesis and Characterization of Magnetic Bioactive Glass Ceramic Thermoseeds Containing Ca Ferrite[J]. Materials Reports, 2018, 32(24): 4211-4216.

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http://www.mater-rep.com/EN/10.11896/j.issn.1005-023X.2018.24.001 OR http://www.mater-rep.com/EN/Y2018/V32/I24/4211

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