基质囊泡及其在骨矿化过程中的作用

doi:10.11896/j.issn.1005-023X.2018.11.009

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Abstract The initial deposition of bone mineral occurs within matrix vesicles (MVs). Calcium phosphate deposition within MVs is triggered by the transmembrane transport and aggregation of calcium & phosphate ions within the MVs lumina through membrane proteins and enzymes when local concentration of calcium & phosphate ions approaches to the certain value. The existence form of calcium phosphate includes amorphous calcium phosphate (ACP), octacalcium phosphate (OCP), and hydroxyapatite (HA). MVs play an important role in initiating bone mineralization process, including controlling calcium & phosphate ions homeostasis, regulating the inorganic phosphate/inorganic pyrophosphate (Pi/PPi) ratio in the intra- and extra-cellular fluid and managing mineral nucleation, etc. This paper introduces the biogenesis, molecular components and extraction method of MVs, illuminates the role and the kinetics of MVs in bone mineralization process. Finally, the research progress of biomimetic mineralization using synthetic phospholipid vesicles as an in vitro mineralization model are discussed.

Key words： matrix vesicles bone mineralization calcium phosphate biomimetic mineralization

Published: 20 July 2018

CLC number:	TB332
	Q291

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	Articles by authors
	HONG Jiadan
	HE Liyong
	YANG Huifang
	WEI Luxi
	PANG Dongwen
	DENG Chunlin

Cite this article:

HONG Jiadan,HE Liyong,YANG Huifang, et al. Matrix Vesicles and Their Role in Bone Mineralization Process[J]. Materials Reports, 2018, 32(11): 1827-1833.

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http://www.mater-rep.com/EN/10.11896/j.issn.1005-023X.2018.11.009 OR http://www.mater-rep.com/EN/Y2018/V32/I11/1827

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