| BIOMEDICAL MATERIALS |
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| Ultrasound-assisted Synthesis of pH-sensitive Macroporous Sodium Alginate-based Hydrogels and Sustained Release |
| WU Chengyi1,2, LI Cong1, ZHANG Xu1, CHENG Chao1, WU Shaowei1, ZHOU Qian1, QIN Shanshan1
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1 Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000;
2 Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Enshi 445000 |
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Abstract A novel macroporous NaAlg-g-poly(NVP-co-NHMAA) was synthesized by a free radical grafting polymerization with ultrasound radiation, the structure and morphologies of NaAlg-g-poly(NVP-co-NHMAA) were characterized by Fourier transform infrared spectroscope (FT-IR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The swelling behavior and pH sensitivity of NaAlg-g-poly(NVP-co-NHMAA) were investigated. 5-Fluorouracil (5-FU) was used as model drug to study the release behavior in simulated gastric fluids (SGF, pH=1.2) and simulated intestinal fluids (SIF, pH=7.4). The results displayed that the cumulative release ratio was up to 80.2% in pH=7.4 for 11 h, only 50.2% in pH=1.2. It means that this hydrogel was suitable for colon-specific drug delivery systems.
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Published: 11 May 2018
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2018, Vol. 32 
