光固化3D打印磷酸钙基生物陶瓷支架的研究进展

doi:10.11896/cldb.22010288

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Abstract Calcium phosphate bioceramic porous scaffolds are commonly used as bone grafts for regenerative repair of bone defects in clinic. Vat polymerization (VP-based) 3D printing techniques are capable of precisely controlling the pore size, pore shape, interconnectivity of scaffold by its excellent printing accuracy and ability of complex structure forming. Therefore, VP-based 3D printing techniques have shown great prospects in the field of fabricating bioceramic porous scaffolds for regenerative repair of bone defects. However, the VP-based 3D printing of calcium phosphate bioceramic porous scaffolds still faces several prickly issues. For example, there is lack of high loading calcium phosphate ceramic slurry with low viscosity and low refractive index difference, and the printing and post-processing processes are immature, and the performance of calcium phosphate ceramic scaffolds needs to be improved. This review briefly introduces the basic principles and characteristics of several commonly used VP-based 3D printing technologies at first, and then systemically explores the research progress and existing problems of VP-based 3D printing techniques in the preparation of calcium phosphate bioceramic porous scaffolds from the aspects of 3D printing forming process, mechanical properties, biological activity, scaffold structure and functionalization. Finally, the development trend and breakthrough points of VP-based 3D printing calcium phosphate bioceramic scaffolds are prospected, in order to provide a new way for the preparation of calcium phosphate bioceramic scaffolds with excellent comprehensive properties and low cost by VP-based 3D printing technologies.

Key words： VP-based 3D printing bioceramic porous scaffold bone defect calcium phosphate

Published: 25 September 2023 Online: 2023-09-18

CLC number:

TB34

Fund:Guangdong Basic and Applied Basic Research Foundation (2021B1515120028), National Natural Science Foundation of China (52130204, 52174376), Science and Technology Innovation Team Plan of Shaanxi Province (2021TD-17), Fundamental Research Funds for the Central Universities (D5000210902), and Innovation Foundation for Doctor Dissertation of NPU(CX2021056, CX2021066).

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	Articles by authors
	DONG Dong
	SU Haijun
	LI Xiang
	ZHAO Di
	FAN Guangrao
	SHEN Zhonglin
	LIU Yuan

Cite this article:

DONG Dong,SU Haijun,LI Xiang, et al. Research Progress on Preparation of Calcium Phosphates Bioceramic Scaffolds by Vat Polymerization 3D Printing[J]. Materials Reports, 2023, 37(18): 22010288-9.

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http://www.mater-rep.com/EN/10.11896/cldb.22010288 OR http://www.mater-rep.com/EN/Y2023/V37/I18/22010288

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