长骨大段骨缺损修复材料的力学性能及制备策略

doi:10.11896/cldb.20060058

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Abstract Autologous bone graft, which is considered as “the gold standard” in repairing large bone defect (LBD), bears limited sources. Alloys and ceramics lead to bone absorption because of stress shielding. Biodegradable materials have good osteogenesis. However, their mechanical properties do not match natural bones. Thus it is the principal goal for treatment of LBD to endow biomaterials with matched mechanical properties similar to cortical bones. The data of four pairs of relationships for hard tissue repair materials, which involve tensile strength-Young' modulus (E), fracture toughness-E, impact strength (toughness)-E, and E-density, show that all these relationships are located outside the scope of cortical bone's mechanical properties and far beyond the center. The microstructure of bone inspires us to discovery new biomaterials. Bone is actually a kind of strong and tough composite material, where inorganic and organic phases are cross-linked as an independent structure respectively, and the two phases are composited and entangled in the molecular level. Therefore, the hard tissue repair materials ought to contain hydroxyapatite (HAp) and biocompatible polymer(s) and be compo-sited on the nanoscale. Ascidian cellulose (AC) has high modulus and possesses great potentiality to enhance bone repair materials. Mild mol-ding conditions including ionic oligomer cross-linking, cold sintering, and fast sintering methods should be employed for the composition of HAp and AC to obtain cortical-bone-matched materials with proper mechanics. This work enumerates the materials employed in LBD, and the existing problem is emphasized. According to the micro structure of bone, the design and preparation strategies of the composite biomaterials are discussed, which may facilitate the research on biomaterial mechanics.

Key words： large bone defects (LBD) man-made bone repair materials mechanical adaption bone micro-structure

Published: 14 July 2021

CLC number:

TQ170

Fund:This work was financially supported by the National Natural Science Foundation of China (51972120, 51772105).

About author:: Qingyou Liang, received his bachelor’s degree in pharmacy from Nanjing Tech University in 2005, supervised by Prof. P. K. Ouyang, and received M. S. degree in pharmaceutical analysis from University of Macau in 2007. After graduation, he joined Analytical and Testing Center, Guangzhou Institute of Chemistry, Chinese Academy of Sciences, as quality deputy. From 2016, he began to serve Analytical and Testing Center, South China University of Technology and is presently the Director of Organic Analysis Department of the center. Now he is supervised by Prof. Chunlin Deng as a Ph. D candidate, making research on bone repair biomaterials and their characterization.
Chunlin Deng, received his Ph. D degree in biomedical engineering from Sichuan University in 2004. Then he serves as a professor in School of Material Science and Engineering of South China University of Technology (SCUT). His research interests are biomimetic minera lization on biomaterial surface, interaction between biomaterials and proteins, and establishment of models of biomineralization in vitro. He has published more than 40 papers in SCI journals such as Biomaterials and worked as the leading scientist in many research programs including 863 projects and NSFC funds.

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Cite this article:

LIANG Qingyou,DENG Chunlin. Mechanical Properties and Preparation Strategies of Bone Repair Materials in the Treatment of Large Bone Defects[J]. Materials Reports, 2021, 35(13): 13100-13108,13118.

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http://www.mater-rep.com/EN/10.11896/cldb.20060058 OR http://www.mater-rep.com/EN/Y2021/V35/I13/13100

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