上转换纳米颗粒的发光机理、制备及生物应用进展

doi:10.11896/cldb.20110168

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Abstract As a new class of fluorescent-labeled materials, rare-earth doped upconversion nanoparticles (UCNPs) can absorb long wavelength near-infrared photons and emit short wavelength UV visible photons. It is capable of efficiently converting two or more low energy photons into high-energy photons. UCNPs have overcome the shortcomings of the traditional fluorescent labeling materials such as low sensitivity and poor photostability, and have become one of the promising alternatives to the traditional labeling materials. UCNPs excited by NIR have many advantages, such as large anti-stokes shift, little damage to biological tissues, high tissue penetration ability, high conversion efficiency, no background fluorescence interference and no photo-bleaching effect. Therefore, it has become a new focus in many fields such as biosensing, imaging, targeted drug delivery, photodynamic therapy and analytical applications for bio-detection due to its outstanding characteristics. In this review, we briefly described the composition, luminescence mechanism and main synthetic methods of UCNPs, and focused on the recent progress in sen-sing, imaging and therapeutic applications. Finally, we reasonably analyzed the current insufficient of UCNPs and gave an outlook on its future development.

Key words： upconversion nanoparticles biosensing bioimaging light activated therapy drug delivery

Published: Online: 2022-07-26

CLC number:	TQ133. 3
	TQ422

Fund:National Key Research and Development Program of China(2018YFC1603500).

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	Articles by authors
	LI Jingzhi
	GAO Zhixian
	LI shuang
	ZHAO Xudong
	QIN Yingkai
	LIU Hui
	HAN Tie

Cite this article:

LI Jingzhi,GAO Zhixian,LI shuang, et al. Advances in Luminescence Mechanism, Preparation and Biological Application of Upconversion Nanoparticles[J]. Materials Reports, 2022, 36(14): 20110168-11.

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http://www.mater-rep.com/EN/10.11896/cldb.20110168 OR http://www.mater-rep.com/EN/Y2022/V36/I14/20110168

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