pH敏感型水凝胶在药物递送中的研究进展

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Abstract Hydrogel is a three-dimensional porous network structure polymer cross-linked by a hydrophilic polymer, which swells in an aqueous solution and is insoluble in water. Due to the unique physical or chemical properties, such as biocompatibility and bioavailability, and the advantages of degradability, hydrophilicity and so on, hydrogel is widely used in the fields of drug release, targeted delivery, tissue engineering, etc. Smart response hydrogels will perceive and respond to small changes and stimuli in the body environment, such as temperature-sensitive hydrogels, pH-sensitive hydrogels, light-sensitive hydrogels, magnetic-sensitive hydrogels, ions-sensitive hydrogels, etc. Among them, pH-sensitive hydrogel is the most common hydrogel, which can produce morphological and structural changes in different pH environments. As a new type of drug delivery carrier material, it has received more and more attention in recent years. The pH-sensitive hydrogel can adjust its own properties or structure according to the different pH values of the human environment, form a semi-solid part of the body, have good adhesion, and be capable of targeted drug delivery.The polymeric materials of pH-sensitive hydrogels mainly include natural polymer materials and synthetic materials. Natural polymer materials include chitosan, carboxymethyl cellulose, and sodium alginate, while artificial synthetic materials include polyacrylic acid, polymethacrylic acid and so on. The preparation methods of pH-sensitive hydrogel mainly include physical cross-linking polymerization method and chemical cross-linking polymerization method. This article reviews the research progress of pH-sensitive hydrogel, and summarizes the latest advances in the common polymer materials, preparation methods, and applications of pH-sensitive hydrogel in the field of drug delivery. The research and application prospects of these are also summarized. A prospect and a reference for the later research and application of pH-sensitive hydrogel are provided.

Key words： pH-sensitive hydrogel carrier material drug delivery

Published: 05 June 2022 Online: 2022-06-08

CLC number:

R943

Fund:National Natural Science Youth Foundation of China (51902216).

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	Articles by authors
	ZHANG Yu
	ZHANG Sida
	DING Xiufang
	ZHANG Ruihua
	CHEN Dong
	XU Jianfu
	FU Qingshan

Cite this article:

ZHANG Yu,ZHANG Sida,DING Xiufang, et al. Research Progress of pH Sensitive Hydrogels in Drug Delivery[J]. Materials Reports, 2022, 36(Z1): 21120138-5.

URL:

http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2022/V36/IZ1/21120138

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