POLYMERS AND POLYMER MATRIX COMPOSITES |
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Research Progress of Self-Healing Hydrogels Based on Dopamine |
HUANG Jinxin, WU Chengwei, YU Xiaogang, MA Jianli, ZHANG Wei
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State Key Laboratory of Structure Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, Dalian 116024, Liaoning, China |
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Abstract Self-healing hydrogels can repair the structure and mechanical properties of damaged parts by reversible dynamic crosslinking in hydrogel networks. Owing to the similar structure and performance to human soft tissues, these hydrogels are widely used in the field of biomedicine. However, self-healing hydrogels still face many problems in practical applications due to the complex environment in the human body. When used as biomaterials, such as implant materials or medical accessories, conventional self-healing hydrogels still lack biocompatibility and tissue adhesion properties. In response to this, dopamine hydrogel combining self-healing properties with a variety of biological characteristics has been developed. These hydrogels not only have the self-healing of mechanical properties, but also have other properties to adapt to the human environment, such as tissue adhesion, biocompatibility, cell adhesion, etc. Firstly, a variety of non-covalent bondings can be formed between the highly active phenolic hydroxyl groups in the polydopamine and the hydrogel polymer network, and the reversible non-covalent bond can be reconstructed on the fracture surface, which makes dopamine hydrogels have excellent self-healing performance. Secondly, the free phenolic hydroxyl groups in the dopamine hydrogel interact with various bio-substrate surface covalently or non-covalently and thereby the hydrogel has good tissue adhesion performance. The highly active phenolic hydroxyl groups can also make dopamine hydrogels have superior cell affinity and cell adhesion properties. It can be seen that the introduction of dopamine provides huge potential for development of self-healing hydrogels. This article reviews the latest research progress of dopamine self-healing hydrogels. According to different self-healing conditions, the self-hea-ling mechanism is analyzed from two directions, namely non-autonomic dopamine self-healing hydrogel and autonomous dopamine self-healing hydrogel. The main factors affecting the self-healing properties of dopamine self-healing hydrogels are analyzed, and the optimization of self-healing properties is prospected.
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Published: 25 April 2022
Online: 2022-04-27
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Fund:National Key R & D Program Project (2018YFA0704103,2018YFA0704104), and the Central University Basic Research Business Expenses Project (DUT21TD105). |
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