Materlals and Sustainable Development:Environment-Friendly Materials and Materials for Environmental Remediation |
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Progress on Stimulus Responsive Smart Hydrogels Based on Natural Polymers |
FAN Zhiping1,*, CHENG Ping2, ZHANG Demeng3, WANG Wenli3, HAN Jun1,
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1 Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, China 2 Liaocheng High-Tech Biotechnology Co.,Ltd., Liaocheng 252059, China 3 State Key Laboratory of Bioactive Seaweed Substances, Qingdao Brightmoon Seaweed Group Co., Ltd., Qingdao 266400, China |
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Abstract atural polymer based hydrogels have been extensively studied in the field of biomedicine due to their excellent biocompatibility, biodegra-dability and biological characteristics. The rapid development of advanced industries, such as flexible devices and biomimetic materials, has further expanded their application fields. Stimulus responsive hydrogel is a kind of intelligent materials, whose network structure can undergo deformation and phase transformation in response to external environmental triggers, resulting in a swelling-shrinking or gel-sol transition behavior. The combination of specific responsive functional groups and materials with natural polymers is usually the main method to give hydrogel stimuli responsiveness. Although traditional hydrogel materials are available, some products still have the following problems: ⅰ. It contains a large number of synthetic polymers, and the synthesis process is complex, high energy consumption and cost; ⅱ.The biocompatibility and degradability of hydrogels are not good, which are not suitable for a series of high-end medical fields, such as implants. ⅲ. After hydrogel forming, the performance is single and immutable, unable to achieve “intelligent” response to external stimuli, and the field of application is severely limited. Compared with traditional hydrogels, stimulus responsive hydrogels have attracted much attention due to their spatial, temporal sensitivity. Re-levant products with multiple, variable and controllable performances have greatly broadened their application fields. In recent years, the vigorous development of natural polymers has provided new opportunities for stimulus responsive hydrogels. At present, the research on natural polymer based stimulus responsive hydrogels mainly focuses on the following aspects: ⅰ. Development of high-end biomedical hydrogels with excellent basic properties and good biocompatibility, biodegradability. ⅱ. Focusing on natural polymer structural modification, giving multiple stimuli responsive properties of materials and preparing multifunctional, multifunctional hydrogels. ⅲ. Development and application of novel non-contact stimulator. ⅳ.Clinical transformation of products with definite efficacy. This review mainly focuses on the design methods, behavior mechanisms and recent application progress of natural polymer based hydrogels with temperature, light, pressure, electrical, magnetic, pH, redox, ionic, sugar and enzymatic responses. Finally, a perspective on the future research directions of natural polymer based hydrogels is briefly discussed.
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Published: 17 November 2020
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Fund:This work was financially supported by the National Science and Technology Major Project of China (2017ZX09201003-013), Natural Science Foundation of Shandong Province (ZR2016EL04), the Open Project of Shandong Collaborative Innovation Center for Antibody (CIC-AD1833), Open Foundation of the State Key Laboratory of Bioactive Seaweed Substances (SKL-BASS1712), Doctoral Starting up Foundation of Liaocheng University (318051609), Tai-Shan Scholar Research Fund of Shandong Province of China (319190201). |
About author:: Zhiping Fan received his M.S. degree in polymer phy-sics and chemistry from Qilu University of Technology (Shandong Academy of Sciences)in 2011, and received his Ph.D. degree in materials science and engineering (biomaterials and tissue engineering) from Southeast University in 2015. In 2016, he joined Liaocheng University, and now is the secretary and a core member of “Tai-Shan Scholar” team. His research interests include drug formulations; drug sustained & controlled release materials, and hydrogel drug delivery system. Ping Cheng received her B.S. degree in chemical engineering and technology from Qilu University of Techno-logy (Shandong Academy of Sciences)in 2008. Currently, she is the director of analysis department of Liaocheng High-Tech Biotechnology Co.,Ltd. Her research has focused on establishment and optimization of drug analysis methods and the drug quality control. She has been involved in more than ten drug development projects, and has experiences in various pharmaceutical formulations including tablets, injections, capsules, sprays and so on. Jun Han obtained his Ph.D. in pharmaceutics from University of Minnesota, and now is the dean for Institute of Biopharmaceutical Research, Liaocheng University. He is also the director for both of Shandong Engineering Research Center for Nanomedicine and Drug Delivery Systems, and Shandong Collaborative Innovation Center for Monoclonal Antibody Drugs. He had working experie-nces with Sanofi, Pfizer, Abbott, Novartis and Teva in drug research & development, and project management. |
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