负载MXene纳米片的冻融水凝胶的制备及防治术后胰瘘的研究

doi:10.11896/cldb.24040053

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Abstract Postoperative pancreatic fistula (POPF) is one of the most common and serious complications after pancreatectomy, resulting in prolonged hospital stays, increased healthcare costs and potentially life-threatening complications. At present, pancreatic duct stents, sealant and polyglycolic acid felt used in clinical prevention and treatment of postoperative pancreatic fistula have certain effects, but they still face problems such as infection and slow healing rate. Inspired by the wound hydrogel dressing, in this study, we prepared PVA-CS-MXene freeze-thaw hydrogel loaded with MXene nanosheets, which has good mechanical properties, swelling behavior, biodegradability and cytocompatibility. In hemocompatibility experiments, the hemolysis rate of hydrogel materials was less than 5%, which proved that PVA-CS hydrogels had good hemocompatibility. Antimicrobial experiments showed that PVA-CS hydrogels had certain antibacterial properties, and the antibacterial properties of the hydrogels were significantly improved by MXene loading. A rat model of postoperative pancreatic fistula was established and wound healing experiment of the residual pancreatic tissue proved that PVA-CS-MXene freeze-thaw hydrogel could inhibit the inflammatory response of the wound and promote the wound healing of the residual pancreatic tissue, so as to effectively prevent and treat postoperative pancreatic fistula. The experimental results show that PVA-CS-MXene freeze-thaw hydrogel is expected to be a promising material for the prevention and treatment of pancreatic fistula after pancreatectomy.

Key words： freeze-thaw hydrogel MXene anti-inflammatory antibacterial wound healing postoperative pancreatic fistula

Published: 10 May 2025 Online: 2025-04-28

CLC number:

R318.08

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	Articles by authors
	LIU Haoheng
	GUO Qianru
	TIAN Jin
	MEN Jie
	LI Kezhou

Cite this article:

LIU Haoheng,GUO Qianru,TIAN Jin, et al. Preparation of Freeze-Thaw Hydrogels Loaded with MXene Nanosheets and Their Prevention and Treatment of Postoperative Pancreatic Fistula[J]. Materials Reports, 2025, 39(9): 24040053-9.

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https://www.mater-rep.com/EN/10.11896/cldb.24040053 OR https://www.mater-rep.com/EN/Y2025/V39/I9/24040053

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