可生物降解壳聚糖半互穿网络水凝胶的制备及胃滞留应用

doi:10.11896/cldb.24040064

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Abstract Gastric retention hydrogels represent a potential material with weight-loss effects and offer an effective solution to address the low bioavailability of drugs in pharmaceutical therapy. This study aims to develop a degradable hydrogel capable of prolonged retention in the stomach, facilitating both weight loss and drug release. Two degradable macromolecular cross-linking agents were synthesized, with acrylamide as the main mo-nomer, mixed with chitosan solution for the preparation of a degradable hydrogel with a semi-interpenetrating network (sIPN) structure initiated by a redox initiator. The morphology and chemical structure of the prepared hydrogels were characterized using analytical techniques such as SEM and FTIR. In vitro drug release experiments demonstrated that the hydrogel achieved controlled drug release, extending the drug's retention time in the stomach. The swelling performance, biocompatibility and degradation properties of the hydrogel in simulated gastric fluid (SGF) were also evaluated. Results indicated that the hydrogel with cross-linking agent ratio 4∶6 exhibited a swelling ratio of 2 700%, excellent biocompatibility and a weight loss of 7% in SGF over 5 days. The 4∶6 hydrogel had a compressive modulus greater than 13 kPa at 60% deformation, demonstrating resistance to gastric peristalsis. Therefore, the chitosan sIPN hydrogel holds promising potential for applications in weight loss and the treatment of gastric diseases.

Key words： degradable hydrogel gastric retention drug release biocompatibility semi-interpenetrating network

Published: 25 April 2025 Online: 2025-04-18

CLC number:

TB324

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	Articles by authors
	DONG Pei
	LIU Yuxin
	ZHANG Peng
	SHENG Yang
	SUN Yixin
	Mark Bradley
	ZHANG Rong

Cite this article:

DONG Pei,LIU Yuxin,ZHANG Peng, et al. Preparation of Biodegradable Chitosan Semi-interpenetrating Network Hydrogel and Its Application for Gastric Retention[J]. Materials Reports, 2025, 39(8): 24040064-9.

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https://www.mater-rep.com/EN/10.11896/cldb.24040064 OR https://www.mater-rep.com/EN/Y2025/V39/I8/24040064

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