原位可注射pH/温度双响应载药水凝胶的制备及抗肿瘤应用

doi:10.11896/cldb.24010129

Abstract
Figure/Table
References
Related Citation (1)

Download:

Full Text ( PDF ) (49858KB)
Export: BibTeX | EndNote (RIS)

Abstract Conventional chemotherapy, though has achieved certain success in cancer treatment, still faces obvious shortcomings including non-specific therapy and serious side effects, intensifying the need for a more precise and effective alternation. In this study, an injectable pH and temperature dual-responsive hydrogel F127/PEI/4PCL-CBA (FECC) was developed. Using pentaerythritol (PETP) as the initiator and SnCl₂ as the catalyst, four-armed star-shaped polycaprolactone (4PCL) was synthesized through the ring opening polymerization reaction of ε-caprolactone (ε-CL). Then the 4PCL was esterified with p-benzaldehyde carboxylic acid (p-CBA) to prepare 4PCL-CBA. And the FECC hydrogel was successfully prepared by mixing 4PCL-CBA, pluronic F127 and polyethyleneimine (PEI) aqueous solution in a certain proportion, which can be crosslinked at 37 ℃ and has good injectability. The doxorubicin (DOX)-loaded FECC hydrogel exhibited a 168-hour DOX release rate of 45.3% with a stable and unhasty release phenomenon under a tumor-like weakly acidic condition, and a cumulative DOX release of only 19.8% in the neutral environment simulating blood circulation. This demonstrates the effective controlled release of the DOX@FECC hydrogel in vitro. In the cell experiment, FECC hydrogel displayed no obvious toxicity to normal vascular endothelial cells (EC), while DOX@FECC hydrogel could signi-ficantly kill the human breast cancer cells (4T1).

Key words： cancer treatment in situ hydrogel pH response temperature response controlled drug release

Published: 25 March 2025 Online: 2025-03-24

CLC number:

TB39

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	JIANG Li
	TANG Zhaomin
	ZHAO Jianqing
	LI Shijie
	LI Haoyu
	YANG Yining
	PAN Xiao
	WANG Xinming

Cite this article:

JIANG Li,TANG Zhaomin,ZHAO Jianqing, et al. In Situ Injectable Drug-loaded pH/Temperature Responsive Hydrogel with Application to Tumor Therapy[J]. Materials Reports, 2025, 39(6): 24010129-7.

URL:

https://www.mater-rep.com/EN/10.11896/cldb.24010129 OR https://www.mater-rep.com/EN/Y2025/V39/I6/24010129

1 Ansa B E, Aldema-Mensah E, Sheats J Q, et al. AJPM Focus, 2023, 2(4), 100121.
2 Stabellini N, Cao L, Towe, C W, et al. Cancer Medicine, DOI:10. 1002/cam4. 6584.
3 Ozawa Y, Hicks K C, Minnar C M, et al. Oncoimmunology, 2021, 10(1), 1915561.
4 Hendriks L, Besse B. Nature, 2018, 558(7710), 376.
5 Danhier F, Feron O, Preat V. Journal of Controlled Release, 2010, 148(2), 135.
6 Tang Z M, Tian W J. Materials Reports, 2022, 36(3), 21120187 (in Chinese).
唐昭敏, 田维君. 材料导报, 2022, 36(3), 21120187.
7 Schmid P, Cortes J, Dent R, et al. New England Journal of Medicine, 2022, 386(6), 556.
8 Zhu Y, Zhu X, Tang C, et al. Biochimica et Biophysica Acta-Reviews on Cancer, 2021, 1876(2), 188593.
9 Spanogiannopoulos P, Kyaw T S, Guthrie B G H, et al. Nature Micro-biology, 2022, 7(10), 1605.
10 Hammerl D, Martens J W M, Timmermans M, et al. Nature Communications, 2021, 12(1), 5668.
11 Szczerba B M, Castro-Giner F, Vetter M, et al. Nature, 2019, 566(7745), 553.
12 Norouzi M, Nazari B, Miller D W. Drug Discovery Today, 2016, 21(11), 1835.
13 Zhao X, Chen X, Yuk H, et al. Chemical Reviews, 2021, 121(8), 4309.
14 Oliva N, Conde J, Wang K, et al. Accounts of Chemical Research, 2017, 50(4), 669.
15 Onaciu A, Munteanu R A, Moldovan A I, et al. Pharmaceutics, 2019, 11(9), 432.
16 Cai L, Liu S, Guo J, et al. Acta Biomaterial, 2020, 113, 84.
17 Raucci M G, D'Amora U, Ronca A, et al. Advanced Healthcare Material, 2020, 9(13), e2000349.
18 Maeda H, Tsukigawa K, Fang J. Microcirculation, 2016, 23(3), 173.
19 Bu Y, Zhang L, Liu J, et al. ACS Applied Material & Interfaces, 2016, 8(20), 12674.
20 Zhou W, Duan Z, Zhao J, et al. Bioactive Material, 2022, 17, 1.
21 Lee S Y, Yang M, Seo J H, et al. ACS Applied Material & Interfaces, 2021, 13(2), 2189.
22 Hopkins C C, de Bruyn J R. Journal of Rheology,2019, 63(1), 191.
23 Zhao R, Wang D, Xie J, et al. Chemical Engineering Journal,2022, 427, 131618.
24 Ding X, Li G, Xiao C, Liu Y, et al. Chemistry and Physics,2019, 220(3), 19000484.
25 Sarkar S, Bera S, Moitra P, et al. Materials Today Chemistry, 2023, 30, 101554.
26 Sun R, Chen Y, Yang Q, et al. International Journal of Pharmaceutics, 2022, 613, 121390.
27 Su M, Zhu Y, Chen J, et al. Chemical Engineering Journal, 2022, 435, 134926.
28 Liu G, Wang L, He Y, et al. Advanced Healthcare Materials, 2021, 10(23), 2101476.
29 Liang Y, Li Z, Huang Y, et al. ACS Nano, 2021, 15(4), 7078.
30 Wu M, Chen J, Huang W, et al. Biomacromolecules, 2020, 21(6), 2409.