| BIOMEDICAL MATERIALS |
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| Ultrasound-assisted Synthesis of pH-sensitive Macroporous Sodium Alginate-based Hydrogels and Sustained Release |
| WU Chengyi1,2, LI Cong1, ZHANG Xu1, CHENG Chao1, WU Shaowei1, ZHOU Qian1, QIN Shanshan1
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1 Department of Chemistry and Environmental Engineering, Hubei University of Nationalities, Enshi 445000;
2 Key Laboratory of Biologic Resources Protection and Utilization of Hubei Province, Enshi 445000 |
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Abstract A novel macroporous NaAlg-g-poly(NVP-co-NHMAA) was synthesized by a free radical grafting polymerization with ultrasound radiation, the structure and morphologies of NaAlg-g-poly(NVP-co-NHMAA) were characterized by Fourier transform infrared spectroscope (FT-IR), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The swelling behavior and pH sensitivity of NaAlg-g-poly(NVP-co-NHMAA) were investigated. 5-Fluorouracil (5-FU) was used as model drug to study the release behavior in simulated gastric fluids (SGF, pH=1.2) and simulated intestinal fluids (SIF, pH=7.4). The results displayed that the cumulative release ratio was up to 80.2% in pH=7.4 for 11 h, only 50.2% in pH=1.2. It means that this hydrogel was suitable for colon-specific drug delivery systems.
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Published: 10 April 2018
Online: 2018-05-11
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1 Wei Q B, Fu F, Zhang Y Q, et al. Synthesis and characterization of pH-responsive carboxymethyl chitosan-g-polyacrylic acid hydrogels[J].Journal of Polymer Research,2015,22:15.
2 Garcia O, Blanco M D, Martin J A, et al. 5-Fluorouracil trapping in poly(2-hydroxyethyl methacrylate-co-acrylamide) hydrogels: In vitro drug delivery studies[J].European Polymer Journal,2000,36:111.
3 Muzzalupo R, Nicoletta F P, Trombino S, et al. A new crown ether as vesicular carrier for 5-fluoruracil: Synthesis, characterization and drug delivery evaluation[J].Colloids and Surfaces B:Biointerfaces,2007,58:197.
4 Singh B, Chauhan N. Preliminary evaluation of molecular imprinting of 5-fluorouracil within hydrogels for use as drug delivery systems[J].Acta Biomaterialia,2008,4:1244.
5 Hussain M, Beale G, Hughes M, et al. Co-delivery of an antisense oligonucleotide and 5-fluorouracil using sustained release poly(lactide-co-glycolide) microsphere formulations for potential combination therapy in cancer[J].International Journal of Pharmaceutics,2002,234:129.
6 Chang C Y, He M, Zhou J P, et al. Swelling behaviors of pH- and salt-responsive cellulose-based hydrogels[J].Macromolecules,2011,44:1642.
7 Artyukhov A A, Shtilman M I, Kuskov A N, et al. Macroporous polymeric hydrogels formed from acrylate modified polyvinyl alcohol macromers[J].Journal of Polymer Research,2011,18:667.
8 Aouada F A, Moura M R D, Orts W J, et al. Preparation and cha-racterization of novel micro- and nanocomposite hydrogels containing cellulosic fibrils[J].Journal of Agricultural and Food Chemistry,2011,59:9433.
9 Wang J C, Ying X G, Liu J Q, et al. Controlled mechanical and swelling properties of urethane acrylate grafted calcium alginate hydrogels[J].International Journal of Biological Macromolecules,2015,81:11.
10Wanga L, Shelton R M, Cooper P R, et al.Evaluation of sodium al-ginate for bone marrow cell tissue engineering[J].Biomaterials,2003,24:3475.
11Venkatesan J, Bhatnagar I, Manivasagan P, et al.Alginate compo-sites for bone tissue engineering:A review[J].International Journal of Biological Macromolecules,2015,72:269.
12Jain M, Garg V K, Kadirvelu K.Cadmium(Ⅱ) sorption and desorption in a fixed bed column using sunflower waste carbon calcium-alginate beads[J].Bioresource Technology,2013,129:242.
13 Polyak B, Geresh S, Marks R S.Synthesis and characterization of a biotin-alginate conjugate and its application in a biosensor construction[J].Biomacromolecules,2004,5:389.
14 Abd El-Ghaffar M A, Hashem, Rabie A M, et al.pH-sensitive so-dium alginate hydrogels for riboflavin controlled release[J].Carbohydrate Polymers,2012,89:667.
15 Hua S, Ma H, Yang H, et al. pH-sensitive sodium alginate/poly(vinyl alcohol) hydrogel beads prepared by combined Ca2+ crosslinking and freeze-thawing cycles for controlled release of diclofenac sodium[J].International Journal of Biological Macromolecules,2010,46:517.
16 He B, Gerpen J H V. Application of ultrasonication in transesterification processes for biodiesel production[J].Biofuels,2012,3:479.
17 Chandralekha E, Thangamani A, Valliappan R. Ultrasound-promoted regioselective and stereoselective synthesis of novel spiroindane-dionepyrrolizidines by multicomponent 1,3-dipolar cycloaddition of azomethine ylides[J].Research on Chemical Intermediates,2013,39:961.
18 Anbarasan R, Jayaseharan J, Sudha M, et al. Sonochemical polymerization of acrylic acid and acrylamide in the presence of a new redox system—A comparative study[J].Journal of Applied Polymer Science,2003,89:3685.
19 Lionetto F, Sannino A, Maffezzoli A. Ultrasonic monitoring of the network formation in superabsorbent cellulose based hydrogels[J].Polymer,2005,46:1796.
20Liu A B, Cai H, Ye B, et al. The damages of high intensity focused ultrasound to transplanted hydatid cysts in abdominal cavities of rabbits with aids of ultrasound contrast agent and superabsorbent polymer[J].Parasitology Research,2013,112:1865.
21Zhang J, Ye B, Kong J, et al. In vitro protoscolicidal effects of high-intensity focused ultrasound enhanced by a superabsorbent polymer[J].Parasitology Research,2013,112:385.
22Jolhe P D, Bhanvase B A, Patil V S, et al. Sonochemical synthesis of peracetic acid in a continuous flow micro-structured reactor[J].Chemical Engineer Journal,2015,276:91.
23 Samanta H S, Ray S K. Synthesis, characterization, swelling and drug release behavior of semi-interpenetrating network hydrogels of sodium alginate and polyacrylamide[J].Carbohydrate Polymers,2014,99:666.
24 Kulkarni R V, Sreedhar V, Mutalik S, et al. Interpenetrating network hydrogel membranes of sodium alginate andpoly(vinyl alcohol) for controlled release of prazosin hydrochloride through skin[J].International Journal of Biological Macromolecules,2010,47:520.
25 Mandal S, Basu S K, Sa B. Ca2+ ion cross-linked interpenetrating network matrix tablets of polyacrylamide-grafted-sodium alginate and sodium alginate for sustained release of diltiazem hydrochloride[J].Carbohydrate Polymers,2010,82:867.
26 Li G Y, Guo L, Chang X J, et al. Thermo-sensitive chitosan based semi-IPN hydrogels for high loading and sustained release of anionic drugs[J].International Journal of Biological Macromolecules,2012,50:899.
27 Wang X H, Zhou Z L, Guo X W, et al. Ultrasonic-assisted synthesis of sodium lignasulfonate-grafted poly(acrylic acid-co-poly(vinyl prrolidone)) hydrogel for drug delivery[J].RSC Advance,2016,6:35550. |
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2018, Vol. 32 
