| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Application of Luminol Self-luminescence in Polyurethane Photosensitizer-mediated Photodynamic Therapy |
| LU Zhengnan1,2, ZHANG Peng1,2, SHENG Yang1,2, SUN Yixin1,2, Mark Bradley2,3, ZHANG Rong1,2,*
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1 School of Materials Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, China
2 Advanced Functional Materials of Jiangsu Joint Laboratory for International Cooperation, Changzhou University, Changzhou 213164, China
3 Precision Healthcare University Research Institute, Queen Mary University of London, London E1 1HH, UK |
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Abstract hotodynamic therapy is currently a promising method for the treatment of cancer and drug-resistant bacterial infections, which usually requires the use of external light sources, which hinders its application in the treatment of deep seated tumors. To overcome this limitation, an attempt was made to use self-luminescent compounds instead of external light sources for the purpose of photodynamic therapy excited by in situ luminescence. In this study, luminol, horseradish peroxidase and hydrogen peroxide were mixed as a self-luminous light source system, and water-soluble polyurethane based on protoporphyrin IX was synthesized as a photosensitizer, which produced singlet oxygen by self-luminescence excitation to achieve the goal of photodynamic therapy. The results showed that the polyurethane photosensitizer could produce singlet oxygen through photodynamic reaction under the excitation of luminol chemiluminescence light source, which effectively killed bacteria and inactivated skin cancer cells, and the photodynamic inactivation effect of bacteria and cells was verified by scanning electron microscopy and fluorescence staining. Therefore, this work confirms that the chemiluminescence of luminol induces the polyurethane photosensitizer to generate singlet oxygen through resonance energy transfer, so as to achieve the purpose of photodynamic therapy, and provides an experimental basis for the further research on the application of photosensitizers in clinical medicine.
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Published: 10 January 2025
Online: 2025-01-10
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2025, Vol. 39 
