1 Public Health School, Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, Inner Mongolia, China 2 Engineering Technology Center of Hygienic Inspection and Assessment of Inner Mongolia Autonomous Region, Baotou 014040, Inner Mongolia, China
Abstract: In this work, NaGdF4:Yb3+, Tm3+ was prepared by the solvothermal method, and the conditions of rare earth ion doping ratio, reaction temperature, reaction time, OA∶ODE volume ratio, and the amount of NH4F were optimized, and the effects on the morphology and properties of the materials were investigated by using XRD, TEM, FTIR, fluorescence spectroscopy, and Zeta potential. The optimal synthesis conditions were determined to be the following: a rare earth ion doping ratio of Gd69%∶Yb30%∶Tm1%, a reaction time of 60 min, a reaction temperature of 300 ℃, an OA∶ODE volume ratio of 5∶15, and an amount of NH4F of 4 mmol, and then the ligand-exchange method was utilized for the preparation of PEI-NaGdF4:Yb3+, Tm3+, which was characterized as PEI-modified nanomaterials. The characterization analysis showed that the crystalline shape of PEI-modified nanomaterials was unchanged compared with that before modification, and the size was homogeneous with a particle size of (26.48±1.03) nm, and the dispersibility and water solubility were good, and the fluorescence intensity was slightly reduced, and the blue up-conversion fluorescence could be emitted under the excitation of the near-infrared light of 980 nm. Zeta potential analysis showed that PEI-NaGdF4:Yb3+, Tm3+, with a positively charged surface, facilitates targeted cellular uptake and provides a material basis for precision medical imaging.
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2025, Vol. 39 
