用于减少再狭窄的食管支架表面功能化策略

doi:10.11896/cldb.25050047

材料导报

2026, Vol. 40

Issue (8): 25050047-7 https://doi.org/10.11896/cldb.25050047

金属与金属基复合材料

用于减少再狭窄的食管支架表面功能化策略

刘晓凤^1,2, 李超婧^1,2, 王富军^1,2, 王璐^1,2,*

1 东华大学纺织学院,上海 201620
2 东华大学纺织面料技术教育部重点实验室,上海 201620

Surface Functionalization Strategies for Esophageal Stents to Reduce Restenosis

LIU Xiaofeng^1,2, LI Chaojing^1,2, WANG Fujun^1,2, WANG Lu^1,2,*

1 College of Textiles, Donghua University, Shanghai 201620, China
2 MOE Key Laboratory of Textile Science & Technology, Donghua University, Shanghai 201620, China

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摘要恶性肿瘤引起食管梗阻,导致患者吞咽困难。缓解恶性梗阻的主要治疗手段之一是支架植入术。然而因肿瘤持续生长和组织增生引发支架植入后再狭窄,这严重影响了患者生活质量和生存期。近年来,国内外研究机构逐步开发基于支架的多模式治疗策略,通过表面功能化技术实现抗狭窄性能,设计了包括防粘附支架、药物洗脱支架、光热支架、内照射支架、光动力支架和“协同治疗”支架等功能性食管支架。本文系统梳理各类支架的设计理念与发展历程,并对食管抗肿瘤支架的长效适应性和靶向治疗增效两个方面的未来发展方向进行了展望。

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关键词: 食管支架再狭窄恶性梗阻表面功能化多模式治疗

Abstract: Malignant esophageal obstruction, predominantly caused by tumors, leads to dysphagia. Stent implantation serves as a key therapeutic intervention for relieving this malignant stenosis. However, post-stent restenosis, primarily driven by persistent tumor proliferation and excessive tissue hyperplasia, significantly compromises patient quality of life and overall survival. Recent years have witnessed significant research endeavors globally focused on developing multimodal therapeutic strategies centered on esophageal stents, leveraging surface functionalization techniques to confer anti-restenotic properties. These advancements encompass a spectrum of functionalized stents, including anti-adhesion stents, drug-eluting stents, photothermal stents, internal radiation stents, photodynamic stents, and synergistic therapy stents. This paper provides a systematic review of the design concepts and evolution of these diverse stent types. Furthermore, it proposes future research directions for esophageal anti-tumor stents, focusing on enhancing long-term biocompatibility/adaptability and optimizing targeted therapeutic efficacy.

Key words: esophageal stent restenosis malignant obstruction surface functionalization multimodal therapy

出版日期: 2026-04-25 发布日期: 2026-05-06

ZTFLH:

R318.08

基金资助: 中国博士后科学基金(2023M732187);111计划2.0(BP0719035)

通讯作者: * 王璐,博士,东华大学纺织学院教授、博士研究生导师。主要研究纺织基医疗器件的功能设计及成型、生物医用纺织材料的结构调控、生物医用材料及其医疗器件的3Bs评价体系等。wanglu@dhu.edu.cn

作者简介: 刘晓凤,东华大学纺织学院博士研究生,在王璐教授的指导下研究医疗器械植入物表面改性设计。

引用本文:

刘晓凤, 李超婧, 王富军, 王璐. 用于减少再狭窄的食管支架表面功能化策略[J]. 材料导报, 2026, 40(8): 25050047-7.
LIU Xiaofeng, LI Chaojing, WANG Fujun, WANG Lu. Surface Functionalization Strategies for Esophageal Stents to Reduce Restenosis. Materials Reports, 2026, 40(8): 25050047-7.

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https://www.mater-rep.com/CN/10.11896/cldb.25050047 或 https://www.mater-rep.com/CN/Y2026/V40/I8/25050047

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