纳米羟基磷灰石对氯氧镁水泥降解性和体外生物活性的影响

doi:10.11896/cldb.22020189

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Abstract Magnesium oxychloride cement(MOC) has the advantages of high strength, good adhesion and non-cytotoxicity, which can be applied in the field of bone repair materials. In this study, nano-hydroxyapatite (n-HAp), a bioactive material, was incorporated into MOC and the effects of n-HAp on water resistance, degradability and bioactivity of MOC were investigated. It was found that the best amount of n-HAp was 10% by mass of magnesium oxide. After soaking in simulated body fluid (SBF) for 28 d, the compressive strength ((29.9±1.8) MPa) and softening coefficient (0.39) of 10% n-HAp-MOC were higher than those of the unmodified MOC, and the mass loss rate (34.5%) was lower than that of the unmodified MOC. The addition of n-HAp enhanced the water resistance of MOC and thereby reduced effectively its degradation rate. Based on XRD analysis and ion concentration change, hydroxyapatite crystals could be deposited on the surface of MOC, indicating that MOC has biological activity. The incorporation of n-HAp promoted the growth of mineralized HAp crystals deposited on the surface of MOC and enhanced the bioactivity of MOC.

Key words： bone cement magnesium oxychloride cement nano-hydroxyapatite water resistance degradability in vitro bioactivity

Published: Online: 2023-12-19

CLC number:

TB321

Fund:Key Technology Research Project of Henan Province, China (222102310112,222102320028) , the Education Department of Henan Province Basic Research Program (19A430015, 19B430004) and the Fundamental Research Funds for the Universities of Henan Province (NSFRF180311).

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	Articles by authors
	LI Hang
	LIAO Jianguo
	MAO Yanrui
	RUAN Wenqiang

Cite this article:

LI Hang,LIAO Jianguo,MAO Yanrui, et al. Effect of Nano-hydroxyapatite on Degradability and in Vitro Bioactivity of Magnesium Oxychloride Cement[J]. Materials Reports, 2023, 37(24): 22020189-5.

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http://www.mater-rep.com/EN/10.11896/cldb.22020189 OR http://www.mater-rep.com/EN/Y2023/V37/I24/22020189

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