| METALS AND METAL MATRIX COMPOSITES |
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| Effect of Magnetron Sputtering Nano-Ag Content on Antibacterial Properties of Titanium Implants |
| CHENG Peixue1, MA Xun1, LIU Ping1, WANG Jingjing1, MA Fengcang1, ZHANG Ke1, CHEN Xiaohong1, LIU Jiannan2,*, LI Wei1,*
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1 School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China
2 Shanghai Ninth People's Hospital Affiliated to School of Medicine of Shanghai Jiao Tong University, Shanghai 200011, China |
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Abstract Pure titanium is widely used in oral implant-related fields because of its excellent biocompatibility, but it does not have antibacterial properties by itself. In order to improve the antibacterial properties of titanium implants surfaces, this paper used magnetron sputtering to prepare Ti-Ag nanocomposite coating on the surface of titanium implants and investigated the effect of nano-Ag content in the coating on the antibacterial properties of Fusobacterium nucleatum (Fn). The surface morphology, roughness and water contact angle of the samples were analyzed; the Ag+ release was examined; the cytotoxicity of the materials was examined by the CCK-8 method; and each group of samples were co-cultured with Fusobacterium nucleatum to examine the antibacterial properties of the materials. The results showed that the Ag-loaded composite coating was successfully deposited on the Ti sheet surface, and the surface roughness and water contact angle of the samples increased with the increase of nano-Ag content. The Ti-Ag nanocomposite coating did not exhibit cytotoxicity to mouse L929 cells and met biosafety standards. The results of antibacterial experiments showed that with the increase of nano-Ag content, the Ag+ release increased and the antibacterial effect of the coating was enhanced. It is concluded that the Ti-Ag nanocomposite coating can effectively inhibit the growth of Fn, which is expected to improve the antibacterial performance of titanium implants and lay an experimental foundation for its clinical application.
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Published: 25 August 2023
Online: 2023-08-14
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| Fund:National Natural Science Foundation of China (51971148). |
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2023, Vol. 37 
