METALS AND METAL MATRIX COMPOSITES |
|
|
|
|
|
Effect of Magnetron Sputtering Nano-Ag Content on Antibacterial Properties of Titanium Implants |
CHENG Peixue1, MA Xun1, LIU Ping1, WANG Jingjing1, MA Fengcang1, ZHANG Ke1, CHEN Xiaohong1, LIU Jiannan2,*, LI Wei1,*
|
1 School of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China 2 Shanghai Ninth People's Hospital Affiliated to School of Medicine of Shanghai Jiao Tong University, Shanghai 200011, China |
|
|
Abstract Pure titanium is widely used in oral implant-related fields because of its excellent biocompatibility, but it does not have antibacterial properties by itself. In order to improve the antibacterial properties of titanium implants surfaces, this paper used magnetron sputtering to prepare Ti-Ag nanocomposite coating on the surface of titanium implants and investigated the effect of nano-Ag content in the coating on the antibacterial properties of Fusobacterium nucleatum (Fn). The surface morphology, roughness and water contact angle of the samples were analyzed; the Ag+ release was examined; the cytotoxicity of the materials was examined by the CCK-8 method; and each group of samples were co-cultured with Fusobacterium nucleatum to examine the antibacterial properties of the materials. The results showed that the Ag-loaded composite coating was successfully deposited on the Ti sheet surface, and the surface roughness and water contact angle of the samples increased with the increase of nano-Ag content. The Ti-Ag nanocomposite coating did not exhibit cytotoxicity to mouse L929 cells and met biosafety standards. The results of antibacterial experiments showed that with the increase of nano-Ag content, the Ag+ release increased and the antibacterial effect of the coating was enhanced. It is concluded that the Ti-Ag nanocomposite coating can effectively inhibit the growth of Fn, which is expected to improve the antibacterial performance of titanium implants and lay an experimental foundation for its clinical application.
|
Published: 25 August 2023
Online: 2023-08-14
|
|
Fund:National Natural Science Foundation of China (51971148). |
|
|
1 Brennan C A, Garrett W S. Nature Reviews Microbiology, 2019, 17 (3), 156. 2 Bui V D, Mwangi J W, Meinshausen A K, et al. Surface and Coatings Technology, 2020, 383, 125. 3 Flores C Y, Diaz C, Rubert A, et al. Journal of Colloid and Interface Science, 2010, 350(2), 402. 4 Alqattan M, Peters L, Yang F, et al. Journal of Alloys and Compounds, 2020, 856, 158165. 5 Diefenbeck M, Schrader C, Gras F, et al. Biomaterials, 2016, 101, 156. 6 Li B, Zhang L, Wang D, et al. Materials Science and Engineering C, 2021, 122, 111878. 7 Kumar R, Umar A, Kumar G, et al. Ceramics International, 2017, 43(5), 3940. 8 Qing Y A, Li R Y, Liu G C, et al. Biological Orthopaedic Materials and Clinical Research, 2017, 14(4), 67 (in Chinese). 卿云安, 李瑞延, 刘贯聪, 等. 生物骨科材料与临床研究, 2017, 14(4), 67. 9 Socol G, Macovei A M, Miroiu F, et al. Materials Science and Enginee-ring B, 2010, 169(1), 159. 10 Liu X J, Gan K, Liu H, et al. Dental Materials, 2017, 33(9), 348. 11 Cao H, Liu X, Meng F, et al. Biomaterials, 2011, 32(3), 693. 12 Qing Y A. Antibacterial properties of TaN-Ag composite coatings on medical titanium alloy surface. Master's Thesis, Jilin University, China, 2019 (in Chinese). 卿云安. 医用钛合金表面TaN-Ag复合涂层抗菌性能的研究. 硕士学位论文, 吉林大学, 2019. 13 Barão V A R, Yoon C J, Mathew M T, et al. Journal of Periodontology, 2014, 85(9), 1275. 14 An Y H, Friedman R J. Journal of Biomedical Materials Research, 1998, 43(3), 338. 15 Sulej-Chojnacka J, Kloskowski T, Borowski J, et al. Journal of Biomaterials and Tissue Engineering, 2016, 6(6), 463. 16 Hauslich L B, Sela M N, Steinberg D, et al. Clinical Oral Implants Research, 2013, 24(A100), 49. 17 Fröjd V, Chávez de P, Andersson M A, et al. Oral Microbiology and Immunology, 2011, 26(4), 241. 18 Bollen C M L, Papaioanno W, Eldere J V, et al. Clinical Oral Implants Research, 1996, 7(3), 201. 19 Das T, Sharma P K, Busscher H J, et al. Applied and Environmental Microbiology, 2010, 76(10), 3405. 20 Drake D R, Paul J, Keller J C. International Journal of Oral and Maxillofacial Implants, 1999, 14(2), 226. 21 Wang H, Lu T, Meng F, et al. Colloids and Surfaces B Biointerfaces, 2014, 117, 89. 22 Sondi I, Salopek-Sondi B. Journal of Colloid and Interface Science, 2004, 275(1), 177. 22030032-523 Ramamurthy C, Padma M, Samadanam I M, et al. Colloids and Surfaces B: Biointerfaces, 2013, 102, 808. 24 Espinosa-Cristóbal L F, Martínez-Castañón G A, Téllez-Déctor E J, et al. Materials Science and Engineering C, 2013, 33(4), 2197. 25 Hernández-Sierra J F, Ruiz F, Pena D C C, et al. Nanomedicine: Nanotechnology, Biology and Medicine, 2008, 4(3), 237. 26 Imazato S, Kinomoto Y, Tarumi H, et al. Dental Materials, 2003, 19(4), 313. |
|
|
|