POLYMERS AND POLYMER MATRIX COMPOSITES |
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Preparation and Performance of Electrospinning Curcumin Loaded Polycaprolactone/Gelatin Bioactive Wound Dressing |
LI Man, WU Dingsheng, WEI Anfang, LIU Suo, ZHAO Lingling, WANG Heng, WANG Kefu, FENG Quan
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Anhui Provincial Key Laboratory of Textile Fabrics, Anhui Polytechnic University, Wuhu 241000, Anhui, China |
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Abstract Curcumin is a polyphenolic compound extracted from turmeric with anti-inflammatory, anti-oxidant, wound healing and other pharmacological activities. It is widely used in food preservation and medicine fields. However, the high crystallinity of curcumin causes its low bioavailability. To solve this problem, electrospinning technology was adopted to load curcumin in PCL/Gelatin nanofibers, and the effect of different mass ratios of polycaprolactone and gelatin on nanofiber membrane's morphology, crystallinity, thermal stability, water uptake capability, water vapor transmission rate, curcumin's release behavior and antioxidant properties was explored in this work. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) curves showed that curcumin in the fiber membrane was amorphous after electrospinning. The water uptake capability of the fiber membrane was positively correlated with the gelatin content and was higher than that of commercial hydrocolloid dressings, while the water vapor transmission rate was equivalent to that of two-layer gauze. Vitro drug release and antioxidant tests showed that the cumulative release rate and free radical scavenging rate of curcumin went up with the increase of the proportion of gelatin in the fiber membrane. The release behaviors of curcumin was analyzed by fitting zero-order, first-order, and Higuchi and Ritger-Peppas drug release mathematical models. The drug release curves of the drug-loaded fiber membranes have the highest fitting coefficients to the first-order release kinetic equation, and the drug release behaviors conformed to the Fick diffusion mechanism.
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Published:
Online: 2022-06-09
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Fund:Natural Science Foundation of Anhui Province (2008085ME139) and Undergraduate Research Project of Textile and Clothing College of Anhui Polytechnic University(2020ffky04). |
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