静电纺丝聚己内酯/明胶载姜黄素生物活性敷料的制备和性能

doi:10.11896/cldb.21010039

Abstract
Figure/Table
References
Related Citation (15)

Download:

Full Text ( PDF ) (5220KB)
Export: BibTeX | EndNote (RIS)

Abstract Curcumin is a polyphenolic compound extracted from turmeric with anti-inflammatory, anti-oxidant, wound healing and other pharmacological activities. It is widely used in food preservation and medicine fields. However, the high crystallinity of curcumin causes its low bioavailability. To solve this problem, electrospinning technology was adopted to load curcumin in PCL/Gelatin nanofibers, and the effect of different mass ratios of polycaprolactone and gelatin on nanofiber membrane's morphology, crystallinity, thermal stability, water uptake capability, water vapor transmission rate, curcumin's release behavior and antioxidant properties was explored in this work. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) curves showed that curcumin in the fiber membrane was amorphous after electrospinning. The water uptake capability of the fiber membrane was positively correlated with the gelatin content and was higher than that of commercial hydrocolloid dressings, while the water vapor transmission rate was equivalent to that of two-layer gauze. Vitro drug release and antioxidant tests showed that the cumulative release rate and free radical scavenging rate of curcumin went up with the increase of the proportion of gelatin in the fiber membrane. The release behaviors of curcumin was analyzed by fitting zero-order, first-order, and Higuchi and Ritger-Peppas drug release mathematical models. The drug release curves of the drug-loaded fiber membranes have the highest fitting coefficients to the first-order release kinetic equation, and the drug release behaviors conformed to the Fick diffusion mechanism.

Key words： electrospinning polycaprolactone gelatin curcumin release kinetics antioxidant

Published: Online: 2022-06-09

CLC number:

TQ34

Fund:Natural Science Foundation of Anhui Province (2008085ME139) and Undergraduate Research Project of Textile and Clothing College of Anhui Polytechnic University(2020ffky04).

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LI Man
	WU Dingsheng
	WEI Anfang
	LIU Suo
	ZHAO Lingling
	WANG Heng
	WANG Kefu
	FENG Quan

Cite this article:

LI Man,WU Dingsheng,WEI Anfang, et al. Preparation and Performance of Electrospinning Curcumin Loaded Polycaprolactone/Gelatin Bioactive Wound Dressing[J]. Materials Reports, 2022, 36(11): 21010039-7.

URL:

http://www.mater-rep.com/EN/10.11896/cldb.21010039 OR http://www.mater-rep.com/EN/Y2022/V36/I11/21010039

1 Zhen Z Z, Li L, Liu W, et al. Journal of Clinical Dermatology, 2017,46(11),824(in Chinese).
郑志忠,李利,刘玮,等. 临床皮肤科杂志, 2017,46(11),824.
2 Zhang T W, Liu F, Tian W Q. Journal of Biomedical Engineering, 2019,36(6),1055(in Chinese).
张天蔚,刘方,田卫群. 生物医学工程学杂志, 2019,36(6),1055.
3 Feng Q, Wu D S, Huan S, et al. Journal of Textile Research, 2016,37(12),12(in Chinese).
凤权,武丁胜,桓珊,等. 纺织学报, 2016, 37(12),12.
4 Dai J M, Fu Y Y, Zhang G Y, et al. Cotton Textile Technology, 2020,48(6),8(in Chinese).
戴家木,付译鋆,张广宇,等. 棉纺织技术, 2020, 48(6),8.
5 Yin Y X, Zhen X E, Lu S T, et al. China Medical Device Information, 2019,25(1),46(in Chinese).
尹玉霞,郑秀娥,鲁守涛,等. 中国医疗器械信息, 2019, 25(1),46.
6 Heriberto Rodríguez-Tobías, Graciela Morales, Daniel Grande. Materials Science & Engineering C, 2019,101,306.
7 Liu Y H, Zhu Z, Wan Q B. Chinese Journal of Tissue Engineering Research, 2020, 24(28),4465(in Chinese).
刘艳华,朱舟,万乾炳. 中国组织工程研究, 2020, 24(28),4465.
8 Hu Y J, Zuo Y, Wu J, et al. Materials Reports B:Research Papers, 2015,29(1),29(in Chinese).
胡运玖,左奕,邬均, 等. 材料导报:研究篇, 2015, 29(1), 29.
9 Deng L L. Fabrication of electrospun composite nanofibers and its relevant application. Ph.D. Thesis, Zhejiang University, China, 2019(in Chinese).
邓伶俐. 基于静电纺丝技术的明胶复合纳米纤维的构建及其应用研究. 博士学位论文, 浙江大学, 2019.
10 Chen W Y, Chen Z J, Yang Z J, et al. Materials Reports, 2021,35(Z2),516(in Chinese).
陈卫英,陈真勇,杨在君,等.材料导报,2021,35(Z2),516.
11 Wang Y. Luteolin loaded electrospun ultrafine fibers for the therapy of gout and its recurrent attacks. Master's Thesis, Southwest Jiaotong University, China, 2016(in Chinese).
王毅. 载木犀草素静电纺超细纤维对痛风及其反复发作的治疗研究. 硕士学位论文, 西南交通大学, 2016.
12 Feng B, Tu H B, Yuan H H,et al. Biomacromolecules, 2012, 13, 3917.
13 Zheng R, Duan H C, Xue J X. Biomaterials, 2014,35(1),152.
14 Chen S Y, Wang Y Y, Wang S F. Ion Exchange and Adsorption, 2016,32(6),493(in Chinese).
陈思原,王园园,王淑芳. 离子交换与吸附, 2016,32(6),493.
15 Ren K, Wang Y, Sun T,et al. Materials Science and Engineering C, 2017,78,324.
16 Wang H, Hao L, Wang P, et al. Food Hydrocolloids, 2017, 63,437.
17 Marziyeh R M, Shahram R, Moayer F, et al. Materials Science and Engineering C, 2016,69,1183.
18 Mona F, Bahrami S H, Marziyeh R M. Journal of Industrial Textiles, 2015,46(2),562.
19 Wu S. Fabrication and drug release characterization of electrospun MWNTs-polycaprolactone/gelatin nanofibers. Master's Thesis, Harbin Engineering University, China, 2019(in Chinese).
吴双. 碳纳米管-聚己内酯/明胶电纺纤维膜的制备及药物释放的研究. 硕士学位论文, 哈尔滨工程大学, 2019.
20 Wang P, Li Y, Zhang C. Food Chemistry, 2020, 308, 125599.
21 Huang G Q, Dong X, Li X D, et al. Journal of Food Safety and Quality, 2019,10(15),5058(in Chinese).
黄国清,董潇,李晓丹,等. 食品安全质量检测学报, 2019, 10(15), 5058.
22 Maria Zahiri, Mehdi Khanmohammadi, Arash Goodarzi, et al. International Journal of Biological Macromolecules, 2020,153, 1241.
23 Sneh Gautam, Amit Kumar Dinda, Narayan Chandra Mishra. Materials Science and Engineering C, 2013,33, 1228
24 Shi Y, Wei Z, Zhao H,et al. Journal of Nanoscience and Nanotechnology, 2013,13,3855.
25 Hu H, Dorset D L. Macromolecules, 1990, 23(21), 4604.
26 Gao X P, Liu J, Tang K Y. Polymer Materials Science & Engineering, 2013, 29(7), 110(in Chinese).
高喜平,刘捷,汤克勇. 高分子材料科学与工程, 2013,29(7), 110.
27 Chen Y, Qiu Y, Wei Q. Materials Science and Engineering C,2020,109, 110536.
28 Fang L. Pharmacy, People's Medical Publishing House, China, 2016(in Chinese).
方亮. 药剂学, 人民卫生出版社, 2016.
29 Salma F G, Tarek M M, Saad M, et al. International Journal of Biological Macromolecules, 2017,105,1148.
30 Zhang J F, Han H L, Shen M M, et al. Food Science, 2020, 41(13), 96(in Chinese).
张婧菲,韩红丽,沈明明,等. 食品科学, 2020, 41(13), 96.
31 Azadeh Ghaee, Shadab Bagheri-Khoulenjani, Hamideh Amir Afshar, et al. Composites Part B, 2019, 177, 107339.
32 Zhou S, Jin H R, Hu J H. Medical Recapitulate, 2015, 21(16), 2983(in Chinese).
周曙,金海蓉,胡晋红. 医学综述, 2015, 21(16), 2983.