POLYMERS AND POLYMER MATRIX COMPOSITES |
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Research Progress of Hydrogel Wound Dressing Based on Natural Polysaccharides |
WANG Tong1, WANG Guangfei1, ZHANG Shumin2,3, QU Chenglei4, LI Chengbo2,4, GAO Yonglin1
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1 College of Life Science, Yantai University, Yantai 264005,Shandong, China 2 Shandong International Biotechnology Park Development Co., Ltd., Yantai 264670,Shandong, China 3 School of Pharmacy, Binzhou Medical University, Yantai 264003,Shandong, China 4 Yantai Blue Bio-technology Co., Ltd., Yantai 264670,Shandong, China |
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Abstract Acute skin injuries and persistent non-healing chronic wounds are common in daily life. Dressings are playing critical roles in wound care because they can protect the wound from external infection and accelerate the healing process. With the characteristics of high porosity, high water content and good biocompatibility, hydrogel dressings have broad application prospects in clinical treatment and tissue engineering. The synthesis methods of hydrogels include the physical cross-linking method and the chemical cross-linking method. Hydrogels prepared by different synthesis methods or different substrates often have different characteristics. Natural polysaccharide hydrogels are far inferior to artificial polymer hydrogels in terms of mechanical properties and stability, and a single polysaccharide hydrogel material may not be able to meet the diversified needs of wound healing. At present, the focus of research is the hybrid double-crosslinked hydrogel which can improve its mechanical properties, and the multi-functional composite hydrogel with antimicrobial properties and biocompatibility. This review gives a summary on the the types of polysaccharides used for hydrogels, the preparation methods and classification of hydrogels based on polysaccharides, and the functional composite hydrogel dressings. In addition, it summarizes the animal experiments, clinical applications and commercial products of hydrogel dressings based on polysaccharides. It hopes to provide a certain reference for relevant researchers in this field.
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Published: 25 March 2022
Online: 2022-03-21
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Fund:Yantai Science and Technology Plan Project (2020XDRH109) and Funding Project for Development and Construction of National Independent Innovation Demonstration Zone in Shandong Peninsula (ZCQ19111). |
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