转铁蛋白在纳米靶向药物递送体系的应用

Abstract
Figure/Table
References
Related Citation (15)

Download:

Full Text ( PDF ) (2292KB)
Export: BibTeX | EndNote (RIS)

Abstract Nano-sized targeted drug delivery systems (TDDS) are the effective method for the diagnosis and treatment of cancer, which is highly accumulated in specific tumor sites, with low side effects and high bioavailability, so it has attracted wide attention. Transferrin receptors are overexpressed on the surface of most cancer cells, but low or not expressed on the surface of normal cells, and have a high affinity with transferrin ligand. Transferrin-coupled TDDS have the advantages of strong targeting and less toxic side effects. This paper mainly discusses the targeting mechanism of TDDS mediated by transferrin receptor, the types of common transferrin functionalized nano-sized targeted drug delivery carriers and three kinds of transferrin functionalized nano-sized TDDS which are still in preclinical research, so as to provide reference and new ideas for further research of TDDS.

Key words： targeted drug delivery system transferrin targeted drug carrier nanoparticles

Published: 09 December 2021

CLC number:	TB324
	R73

Fund:This work was financially supported by the National Natural Science Foundation of China (21664007).

About author:: Shuiling Yi graduated from Hunan University of Medicine with a major in medical laboratory technology in 2020. At present, she is a master's graduate student from School of Life Science,Jiangxi Science and Technology Normal University. She is performing research under the guidance of Prof. Xiangyuan Xiong. Her research interest focuses on polymer biomedical materials, such as the synthesis and characterization of transferrin targeted nanoparticles and related cytotoxicity and drug uptake.
Xiangyuan Xiong is currently a professor at Schoolof Jiangxi Science and Technology Normal University and an academic and technical leader of major disciplines of Jiangxi Province. She was selected for the candidate as the “One Million Talents Project of Jiangxi Provincein 2009” and an advanced worker of Nanchang City in 2010. She obtained her M. E. degree in polymer chemi-stry and physics from Peking University in 2001. Subsequently, she pursued advanced studies in Nanyang Technological University(NTU)and received her Ph. D. degree in May 2005.
She served as research associate of Singapore-MIT Alliance(SMA)in Aug. 2004—Mar. 2005. She specializes in nano-scale polymer vehicles, including the controllable synthesis and characterization of biocompatible and biodegrada-ble block copolymers, the aggregation morphology and particle size in water. In addition, she focuses on the application research of nanoparticles in the biomedical field, especially the controlled release system and targeted release system. She has published more than 20 SCI papers in the Journal of Controlled Release, Nanomedicine and other well-known international journals. She acquired the second prize of “the Higher School Science and Technology Achievement Award of Jiangxi Province” in 2007-2008 and the third prize of “the Natural Science Award of Jiangxi Province” in 2009.

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YI Shuiling
	XIONG Xiangyuan

Cite this article:

YI Shuiling,XIONG Xiangyuan. Application of Transferrin in Nano-sized Targeted Drug Delivery Systems[J]. Materials Reports, 2021, 35(z2): 501-507.

URL:

http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2021/V35/Iz2/501

1 Wang Z, Zhi K, Ding Z, et al. Seminars in Cancer Biology, 2021, 69, 77.
2 Tran P H L, Xiang D, Tran T T D, et al. Advanced Materials, 2020, 32(18), e1904040.
3 Agrawal M, Saraf S, Saraf S, et al. Journal of Controlled Release, 2020, 321, 372.
4 Sharma G, Lakkadwala S, Modgil A, et al. International Journal of Molecular Sciences, 2016, 17(6),806.
5 Zhang Y, Sun T, Jiang C. Acta Pharmaceutica Sinica B, 2018, 8(1), 34.
6 Fernandes M A, Hanck-Silva G, Baveloni F G, et al. Critical Reviews in Analytical Chemistry, 2020, 51(5), 399.
7 Jhaveri A, Luther E, Torchilin V. Journal of Drug Targeting, 2019, 27(5-6), 601.
8 Muddineti O S, Kumari P, Ghosh B, et al. Pharmaceutical Research, 2018, 35(5), 97.
9 Agrawal P, Sonali, Singh R P, et al. Colloids and Surfaces B: Biointerfaces, 2017, 152, 277.
10 Gammella E, Buratti P, Cairo G, et al. Metallomics, 2017, 9(10), 1367.
11 Johnsen K B, Burkhart A, Thomsen L B, et al. Progress in Neurobiology, 2019, 181, 101665.
12 Khan A I, Liu J, Dutta P. Biochim Biophys Acta General Subjects, 2018, 1862(5), 1168.
13 Choudhury H, Pandey M, Chin P X, et al. Drug Delivery and Translational Research, 2018, 8(5), 1545.
14 Dos Santos Rodrigues B, Kanekiyo T, Singh J. Nanomedicine: Nanotechnology, Biology, and Medicine, 2020, 28, 102225.
15 Olsman M, Sereti V, Muhlenpfordt M, et al. Ultrasound in Medicine & Biology, 2021, 47(5), 1343.
16 Wu S, Fu J, Liu D, et al. American Chemical Society Biomaterials Science & Engineering, 2020, 6(11), 6207.
17 Fang Z, Sun Y, Cai C, et al. International Journal of Polymeric Materials and Polymeric Biomaterials, 2019, 70(1), 27.
18 Pardo J, Peng Z, Leblanc R M. Molecules, 2018, 23(2),378.
19 Aires Fernandes M, Eloy J O, Tavares Luiz M, et al. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021, 611,125806.
20 Wang K, Shang F, Chen D, et al. Journal of Nanobiotechnology, 2021, 19(1), 31.
21 Alsawaftah N M, Awad N S, Paul V, et al. Scientific Reports, 2021, 11(1), 11589.
22 Fu J, Li W, Xin X, et al. Journal of Pharmaceutical Sciences, 2020, 109(8), 2426.
23 Dos Santos Rodrigues B, Lakkadwala S, Kanekiyo T, et al. Journal of pharmacology and experimental therapeutics, 2020, 374(3), 354.
24 Lakkadwala S, Singh J. Colloids and Surfaces B: Biointerfaces, 2019, 173, 27.
25 Zou W, Sarisozen C, Torchilin V P. Journal of Drug Targeting, 2017, 25(3), 225.
26 Zhang X, Zhao L, Zhai G, et al. Medical Science Monitor, 2019, 25, 9737.
27 Debele T A, Wu P C, Wei Y F, et al. Cancers, 2021, 13(10), 2375.
28 Wei Y, Gu X, Cheng L, et al. Acta Biomaterialia, 2019, 92, 196.
29 Wei Y, Gu X, Sun Y, et al. Journal of Controlled Release, 2020, 319, 407.
30 Li J, Lee M M S, Li H, et al. American Chemical Society Appl Mater Interfaces, 2020, 12(26), 29641.
31 Bhatt H, Rompicharla V K, Ghosh B, et al. Nanomedicine: Nanotechnology, Biology, and Medicine, 2019, 14(24), 3159.
32 Hu Q, Wang Y, Xu L, et al. International Journal of Nanomedicine, 2020, 15, 2751.
33 Zhang Q, Li J, Tang P, et al. Nanomaterials (Basel), 2019, 9(10), 1373.
34 Zhou Y, Zhou J, Wang F, et al. Talanta, 2018, 181, 248.
35 Saini K, Bandyopadhyaya R. American Chemical Society Applied Nano Materials, 2019, 3(1), 229.
36 Chen X, Sun H, Hu J, et al. Colloids and Surfaces B: Biointerfaces, 2017, 152, 77.
37 Li S, Amat D, Peng Z, et al. Nanoscale, 2016, 8(37), 16662.
38 Hettiarachchi S D, Graham R M, Mintz K J, et al. Nanoscale, 2019, 11(13), 6192.
39 Praphakar R A, Munusamy M A, Rajan M. International Journal of Pharmaceutics, 2017, 524(1-2), 168.
40 Wang G, Zhao X, Wu H, et al. Small, 2020, 16(39), e2003654.
41 Montalvo-Quiros S, Aragoneses-Cazorla G, Garcia-Alcalde L, et al. Nanoscale, 2019, 11(10), 4531.
42 Singh R P, Sharma G, Sonali, et al. Materials Science & Engineering C: Materials for Biological Applications, 2016, 67, 313.
43 Zhang T, Guo W, Zhang C, et al. American Chemical Society Applied Materials & Interfaces, 2017, 9(19), 16006.
44 Kim S S, Harford J B, Moghe M, et al. International Journal of Cancer, 2019, 145(9), 2535.
45 Shi J, Kantoff P W, Wooster R, et al. Nature Reviews: Cancer, 2017, 17(1), 20.
46 Kim S S, Harford J B, Moghe M, et al. Oncoimmunology, 2018, 7(10), e1484982.
47 Pirollo K F, Nemunaitis J, Leung P K, et al. Molecular Therapy, 2016, 24(9), 1697.
48 He H, Liu L, Morin E E, et al. Accounts of Chemical Research, 2019, 52(9), 2445.
49 Siefker-Radtke A, Zhang X Q, Guo C C, et al. Molecular Therapy, 2016, 24(8), 1484.
50 Meel R V D, Vehmeijer L J, Kok R J, et al. Advanced Drug Delivery Reviews, 2013, 65(10), 1284.
51 Zuckerman J E, Gritli I, Tolcher A, et al. Proceedings of the National Academy of Sciences of the United States of America, 2014, 111(31), 11449.