Materials Reports  2021, Vol. 35 Issue (z2): 508-512 |
| POLYMERS AND POLYMER MATRIX COMPOSITES |
|
|
|
|
|
| Fabrication and Performance of pH-responsive Polymer-based 3D Nanofibers |
| LEI Ying, GE Chongchong, FENG Jin, SHANG Jiaojiao
|
| College of Biomass Science and Engineering, Sichuan University, Chengdu 610065, China |
|
|
|
|
Abstract Diethyl methacrylate (DEAEMA), methyl methacrylate (MMA) and 4-acrylloxybenzophenone (ABP) were used as monomers to prepare a series of photo-initiable cross-linked polymer P(DEAEMA-co-MMA-co-ABP) by free radical polymerization and then the synthesized copolymer was spun to be nanofibers. Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic field (1H NMR), gel penetration chromatography (GPC), thermogravimetric analysis (TGA) were used to test and characterize the chemical composition, structure and properties of the copolymers. The morphology of the nanofibers was characterized by optical and scanning electron microscopy (SEM), and the pH responsiveness of both synthesized copolymer and the cross-linked nanofibers were studied via changing the pH of solutions. The results show that the copolymer with 80∶10∶10 molar ratio of DEAEMA/MMA/ABP exhibits sensitive pH response, and the nanofibers with uniform morphology can be spun under the conditions with volume ratio of DMF/THF at 1∶9 and mass concentration of copolymer at 40wt%. Moreover, the cross-linked 3D nanofibrous mats have the properties of reversible swelling and contraction in acid-base solutions. Such nanofibrous mats can be used in the fields of controlled drug release and tissue carrier.
|
|
Published: 09 December 2021
|
|
|
| Fund:This work was financially supported the Fundamental Research Funds for the Central Universities (YJ201959), Science and Technology Support Program of Sichuan Province (2021YJ0290). |
About author:: Ying Lei, an undergraduate of the College of Biomass Science and Engineering, Sichuan University, majored in Textile Materials Engineering. She has undertaken a provincial College Students' Innovative Entrepreneurial Training Plan Program. The main research work focused on the synthesis of stimuli-responsive polymers by free radical polymerization and the construction of responsive nanofibrous drug carriers and actuators based on cross-linked thermal and pH response nanofibers
Jiaojiao Shang, an associate professor at the College of Biomass Science and Engineering, Sichuan University. Prof. Shang graduated from the Department of Chemistry, University of Hamburg, Germany, and then she joined Sichuan University via an overseas talent program in 2019. Currently, she is engaged in the following research work: (1) the application of responsive “smart” materials in flexible actuators and sensors based on polymer synthesis and molecular modification techniques;
(2) application of biomass materials in the field of advanced materials science. Focusing on stimuli-responsive materials, she has synthesized a series of stimuli-responsive functional monomers and functionalize them to be applied in nanofiber sensors, actuators, and responsive drug delivery systems by controlled polymerization, nanocrystallization, click chemistry, and other technologies. In the development of biomass materials, she mainly engaged in the development of natural materials in optical materials and biomedical applications. Based on the above researches, more than 50 journal articles have been published. |
|
|
1 Gao Y, Wei M, Li X. et al.Macromolecular Research, 2017, 25, 513.
2 Li Z, Li G, Hu Y.Progress in Chemistry, 2017, 29(12), 1480.
3 Joseph S K, Sabitha M, Nair S C. Advanced Pharmaceutical Bulletin, 2020, 10(1), 1.
4 Tang H, Zhao W, Yu J. et al. Molecules. 2019, 24(1), 4.
5 Ye M, Zhao Y, Wang Y. et al.Advanced Functional Materials,2020, 30(39), 2002655.
6 Kocak G, Tuncer C, Bütün V.Polymer Chemistry,2017,8, 144.
7 Li S, Hu K, Cao W. et al.Nanoscale, 2014, 6, 13701.
8 Wu M, Chen J, Huang W. et al. Biomacromolecules , 2020, 21(6), 2409.
9 Cai X, Yang X, Wang F. et al.Journal of Biomedical Nanotechnology, 2016, 12(7), 1453.
10 Deirram N, Zhang C, Kermaniyan S S. et al. Macromolecular Rapid Communications,2019,40(10),1800917.
11 Guo H, Tan S, Gao J. et al. Journal of Materials Chemistry B, 2020,8, 1759.
12 Gupta P, Purwar R.Journal of Polymer Research, 2020, 27(10),296.
13 Zhang J, Xu C, Ren Y. et al.Micro & Nano Letters, 2020, 15(8), 524.
14 赵玥,冯媛媛. 高分子材料科学与工程, 2020, 36(12), 116.
15 谢贤莉,张培松,刘春华,等. 高分子材料科学与工程, 2020, 36 (8),146.
16 Chen S, Sun G.ACS Applied Materials & Interfaces,2013, 5 (14), 6473.
17 Ding B, Wang M, Wang X. et al.Materials Today,2010, 13, 16.
18 Wang Y, Liang Z, Su Z. et al.ACS Applied Bio Materials, 2018, 1, 1398.
19 Khodadadi M, Alijani S, Montazeri M. et al.Journal of Biomedical Materials Research. Part A,2020, 108(7),1444.
20 Thao N T T, Lee S, Shin G R. et al. Pharmaceutics,2021, 13(2), 253.
21 Tort S, Han D, Steckl A J. International Journal of Pharmaceutics, 2020,579(15),11964.
22 Shang J, Lin S, Theato P.Polymer Chemistry,2017, 8,7446. |
|
|
|
渝公网安备50019002502923号 © Editorial Office of Materials Reports.
