介孔二氧化硅门控开关在分析检测中的研究进展

doi:10.11896/cldb.20050051

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Abstract Mesoporous silica nanoparticles can be used as excellent carriers for photoactive and chemically active substances due to their unique structural characteristics and physicochemical properties. The blocking action to the inclusions and targeting effect to analytes could be realized when mesoporous silica nanoparticles were modified and functionalized by small molecule compounds, nucleic acids, antibodies, proteins and other functional molecules. Intelligent nano-gated switches based on mesoporous silica nanoparticles and functional molecules have been used for the analysis and detection of small molecular compounds such as disease-related biomarkers, chemical warfare agents, explosives, drugs. In addition, intelligent nano-gated switches have been gradually applied to the construction of highly sensitive chemical sensors. In this paper, combined with the functionalization design of mesoporous silica nanoparticles and the existing scientific problems in application, the recent advances of mesoporous silica nanoparticles in the construction of fluorescent probes and chemical sensors are reviewed, and the future development direction is prospected.

Key words： mesoporous silica nano-gated switches fluorescent probes chemical sensors functional molecules

Published: 31 August 2021

CLC number:	O613.72
	TB381
	O65
	TP212

Fund:Military Scientific Research Project.

About author:: Yan Zhangreceived his B.E. degree from Shenyang Pharmaceutical University in 2018. He is currently pursuing his M.S. degree at Tianjin University and Academy of Military Medical Sciences under the supervision of associate researcher Zhiyong Nie. His research has focused on drug analysis.
Jin Zhao, associate researcher. She received her Ph.D. degree in military preventive medicine from the Chinese Academy of Military Medical Sciences (AMMS) in 2006. She has been mainly engaged in military pharmacy research and management for a long time, and has published more than 30 papers.
Zhiyong Nie, associate researcher. He received his Ph.D. degree in pharmaceutical analysis from the Chinese Academy of Military Medical Sciences (AMMS) in 2011. His research interests include the detection and identification of toxicants, inhalation toxicology analysis, countermeasures against poisoning. He has published more than 30 papers in Food Chemistry, Talanta, Scientia Sinica and so on, and participated in the compilation of several monographs and textbooks. He has gained two scientific and technological awards, and won three times of indivi-dual class three merit citations during combating the earthquake and carrying out relief work and doing other chemical emergency rescue works.

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	ZHANG Yan
	ZHU Yongle
	HUANG Lijuan
	WANG Yongan
	ZHAO Jin
	NIE Zhiyong

Cite this article:

ZHANG Yan,ZHU Yongle,HUANG Lijuan, et al. Advances of Mesoporous Silica Gated Switches in Analysis and Detection[J]. Materials Reports, 2021, 35(15): 15081-15087.

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http://www.mater-rep.com/EN/10.11896/cldb.20050051 OR http://www.mater-rep.com/EN/Y2021/V35/I15/15081

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