POLYMERS AND POLYMER MATRIX COMPOSITES |
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Mechanical-Chemical Properties of Nanomaterial Doped Poly(vinyl alcohol) Dual Cross-linked Hydrogels |
XUE Yanan1, HAN Zhengxue1, LI Shuangran1, ZHANG Jiayu1, ZHANG Xuehui1 , WANG Zhaowei1, JIA Ruijie1, WANG Yanqin1,2, WU Xiaogang1, LI Xiaona1, CHEN Weiyi1
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1 School of Biomedical Engineering, Taiyuan University of Technology, Taiyuan 030024 2 State Key Laboratory of Luminescent Materials and Devices, South China University of Technology, Guangzhou 510640 |
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Abstract In the present work, a series of graphene oxide (GO)/hydroxyapatite (HA)/poly(vinyl alcohol)(PVA) dual cross-linked composite hydrogels were synthesized by applying the combinatorial methods of chemical crosslinking and cyclic freezing-thawing, and varying the mass ra-tios of GO to PVA, HA to PVA and the number of times of cyclic freezing-thawing. Firstly, PVA chains covalently crosslinked at a rather low concentration (considering the bio-safety) of glutaraldehyde for the chemical-crosslinking of the first network. Then, during the cyclic freezing-thawing process, the PVA crystalline domains served as cross-linking knots and the hydrogen-bonding were formed for the secondary physical-crosslinking network. The resultant hydrogels were defined as the GO/HA/PVA dual cross-linked hydrogels. The structure of the GO/HA/PVA nanocomposite hydrogels was characterized by the high-resolution scanning electron microscope and X-ray diffraction. The tensile mechanical properties were further investigated for the dual cross-linked hydrogels differing in mass ratios of GO to PVA (0%—2.6%) and HA to PVA (0.22—1.10), and number of times of cyclic freezing-thawing (0, 3, 7). When the mass ratio of GO/PVA reached to 1.9%, HA/PVA reached to 0.66 and with 7 times cyclic freezing-thawing, the GO/HA/PVA dual cross-linked hydrogel achieved the maximum tensile strength and elongation at break of up to 695 kPa and 286%, and the Young's modulus was 78 kPa. We further investigated the water content and swelling behaviors of dual cross-linked hydrogels with various number of times of cyclic freezing-thawing (0, 3, 7). The results revealed that the water content was about 79.3%—81.7%, and the equilibrium swelling ratio was about 50.1%—72%. The hydrogel was expected to serve as cartilage substitution materials in clinical medicine field.
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Published: 16 May 2019
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Fund:This work was financially supported by the National Natural Science Foundation of China (11702183, 11632013, 11572213,11872262), Natural Science Foundation of Shanxi (2016021145), the State Key Laboratory of Fine Chemicals (KF1511), the State Key Laboratory of Luminescent Materials and Devices (2019-skllmd-21). |
About author:: Yanan Xue currently works at Taiyuan University of Technology. At present, the main research direction is the fabrication of biomedical polymer materials and the analysis of mechanical and chemical properties. Yanqin Wang received her Ph.D. degree in analytical chemistry from the Nankai university in 2013 and served in Taiyuan university of technology till now. She is currently an associate professor and master supervisor enjoying the National Natural Science Youth Fund, Natural Science Foundation of Shanxi Youth Fund. Her team's research interests focus on the fabrication of the biome-dical polymer materials and nano fluorescence sensors. |
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