荧光碳量子点:合成、特性及在肿瘤治疗中的应用

doi:10.11896/cldb.18030145

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Abstract Carbon quantum dots (CDs or C-dots) are novel fluorescent nano-materials mainly composed of carbon. As a member of nanomaterials, CDs show the common surface and interface effects, hence the surface of CDs is greatly active and prone to be modified. Thanks to the small size effect and quantum size effect, CDs are also endowed with excellent fluorescence performance, exhibiting high quantum yield, stability and controllable properties. In addition, the excellent water solubility, low cytotoxicity, satisfactory biocompatibility, small particle size and molecular weight are favorable for the application of CDs in vivo. The above mentioned outstanding properties of CDs enable the widespread applications of CDs in diverse fields, including tumor imaging, detection, targeting and therapy. Just from the perspective of tumor therapy, the applications of CDs have deeply penetrated in traditional and emerging approaches already.
Taking advantages of CDs, researchers commonly employ nano-drug delivery system to optimize the chemotherapy. It uses nanomaterials as the basic unit, then the drugs are absorbed or encapsulated onto the nano-carriers through physical or chemical connection, and finally to achieve a better anticancer effect by the special properties of nano-carriers. Accordingly, CDs play a significant role in chemotherapy process due to their excellent performance. Specifically speaking, CDs can enhance the therapeutic effect by improving the water solubility of drug, reduce the da-mage of drugs to the normal cells by improving the targeting ability to the lesion, prolong the retention time of the drug, and realize the intelligent and efficient drug release.
Furthermore, the characteristic of photothermal conversion and photoluminescence properties of CDs have also paved the way for extensive application of CDs in many emerging therapeutic approaches, such as photothermal therapy and photodynamic therapy. As regard to hyperthermia treatment, CDs can significantly improve the safety and efficiency. In photodynamic therapy, CDs contribute to improve the solubility, quantum yield of photosensitizer, penetration depth of light source and oxygen supply around cancerous tissue. The CDs in multiple treatments can also boost the therapeutic effect to the maximum.
In this article, we introduce the synthesis approaches and latest progress in CDs preparation, summarize the excellent properties of CDs in tumor therapy, and put emphasis on frontier application of CDs in cancer therapy including photodynamic therapy, photothermal therapy and chemotherapy.

Key words： carbon dots fluorescent nano-materials cancer therapy

Published: 08 May 2019

CLC number:

TQ174

Fund:This work was financially supported by the National Natural Sciences Foundation of China (51502345), and Tianjin Sciences Foundation (16JCQNJC03100).

About author:: Kun Yang received her B.S. degree in Tianjin University in June 2013. He is currently pursuing his Ph.D. at the Institute of Medical Support Technology, Academy of Military Sciences. His research has focused on carbon nano-materials and their applications. Fan Li, Ph.D., is now a senior engineer of Institute of Medical Support Technology, Academy of Military Sciences. His research interests are carbon nanomate-rials’ applications on fluorescence labeling, light-energy conversion, photocatalysis and so on. He has taken charge of more than 10 projects, including Natural Sciences Foundation of China, Tianjin Sciences Foundation and some military projects.

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	YANG Kun
	WANG Chunlai
	DING Sheng
	LIU Changjun
	TIAN Feng
	LI Fan

Cite this article:

YANG Kun,WANG Chunlai,DING Sheng, et al. A State-of-the-art Review on Fluorescent Carbon Quantum Dots: Fabrication,Characterization and Potential in Cancer Therapy[J]. Materials Reports, 2019, 33(9): 1475-1482.

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http://www.mater-rep.com/EN/10.11896/cldb.18030145 OR http://www.mater-rep.com/EN/Y2019/V33/I9/1475

1 Du F, Zhang L, Zhang L, Zhang M, et al. Biomaterials,2017,121,109.
2 Yan P, Ai F R, Yan X L, et al. Materials Review A:Review Papers,2017,31(10),35(in Chinese).
闫鹏,艾凡荣,严喜鸾,等.材料导报:综述篇,2017,31(10),35.
3 Tuerhong M, Xu Y, Yin X B. Chinese Journal of Analytical Chemistry,2017,45,139.
4 Che W Y, Liu C J, Yang K, et al. Acta Materiae Compositae Sinica,2016,33(3),431(in Chinese).
车望远,刘长军,杨焜,等.复合材料学报,2016,33(3),431.
5 Qiao Z A, Wang Y, Gao Y, et al. Chemical Communications,2010,46(46),8812.
6 Peng J, Gao W, Gupta B K, et al. Nano Letters,2012,12(2),844.
7 Shinde D B, Pillai V K. Chemistry—A European Journal,2012,18(39),12522.
8 Wang X, Qu K, Xu B, et al. Journal of Materials Chemistry,2011,21(8),2445.
9 Yang K, Li F, Che W, et al. RSC Advances,2016,6(103),101447.
10Bourlinos A B, Stassinopoulos A, Anglos D, et al. Chemistry of Mate-rials,2008,20(14),4539.
11Pei S, Zhang J, Gao M, et al. Journal of Colloid and Interface Science,2015,439,129.
12Mehta V N, Jha S, Kailasa S K. Materials Science and Engineering: C,2014,38,20.
13Zhang Z, Hao J, Zhang J, et al. RSC Advances,2012,2(23),8599.
14Mandani S, Dey D, Sharma B, et al. Carbon,2017,119,569.
15Liu W, Diao H, Chang H, et al. Sensors and Actuators B: Chemical,2017,241,190.
16Qu D, Miao X, Wang X, et al. Journal of Materials Chemistry B,2017,5,4988.
17Shi W, Guo F, Han M, et al. Journal of Materials Chemistry B,2017,5,3293.
18Li C, Zhu Y, Zhang X, et al. RSC Advances,2012,2(5),1765.
19Jiang K, Sun S, Zhang L, et al. ACS Applied Materials & Interfaces,2015,7,23231.
20Ding H, Ji Y, Wei J S, et al. Journal of Materials Chemistry B,2017,5,5272.
21Zhang Y, Liu X, Fan Y, et al. Nanoscale,2016,8,15281.
22Liu X, Yang C, Zheng B, et al. Sensors and Actuators B: Chemical,2018,255,572.
23Baker S, Baker G. Angewandte Chemie International Edition,2010,49(38),6726.
24Li H, He X, Kang Z, et al. Angewandte Chemie International Edition,2010,49(26),4430.
25Kwon W, Rhee S. Chemical Communications,2012,48(43),5256.
26Liu H, Ye T, Mao C. Angewandte Chemie International Edition,2007,46(34),6473.
27Yu P, Wen X, Toh Y, et al. The Journal of Physical Chemistry C,2012,116(48),25552.
28Ensafi A A, Hghighat Sefat S, et al. Sensors and Actuators B: Chemical,2017,253,451.
29Han B, Wang W, Wu H, et al. Colloids and Surfaces B: Biointerfaces,2012,100,209.
30Zhong Y, Li J, Jiao Y, et al. Journal of Luminescence,2017,190,188.
31Li S, Amat D, Peng Z, et al. Nanoscale,2016,8(37),16662.
32Pandey S, Thakur M, Mewada A, et al. Journal of Materials Chemistry B,2013,1(38),4972.
33Gao N, Yang W, Nie H, et al. Biosensors and Bioelectronics,2017,96,300.
34Jia X, Li J, Wang E. Nanoscale,2012,4(18),5572.
35Wang H, Shen J, Li Y, et al. Biomaterials Science,2014,2(6),915.
36Lan M, Zhao S, Zhang Z, et al. Nano Research,2017,10(9),3113.
37Zhang M, Yuan P, Zhou N, et al. RSC Advances,2017,7(15),9347.
38Liu J, Huang Y, Kumar A, et al. Biotechnology Advances,2014,32(4),693.
39Dolmans D E, Fukumura D, Jain R K. Nature Reviews Cancer,2003,3(5),380.
40Zhang Y, Wang F, Liu C, et al. ACS Nano,2018,12(1),651.
41Garg A D, Krysko D V, Vandenabeele P, et al. Cancer Immunology, Immunotherapy,2018,67(7),1179.
42Huang P, Lin J, et al. Advanced Materials,2012,24(37),5104.
43Yang K, Li F, Che W, et al. RSC Advances,2016,6(103),101447.
44Fowley C, Nomikou N, McHale A, et al. Chemical Communications,2013,49(79),8934.
45Wang J, Zhang Z, Zha S, et al. Biomaterials,2014,35(34),9372.
46Zhao N, Wu B, Hu X, et al. Biomaterials,2017,141,40.
47Zhang Y, Pang L, et al. Analytical Chemistry,2014,86,3092.
48Xu J, Zeng F, Wu H, et al. Journal of Materials Chemistry B,2015,3(24),4904.
49Fowley C, McHale A, McCaughan B, et al. Chemical Communications,2015,51(1),81.
50Ge J, Jia Q, Liu W, et al. Advanced Materials,2015,27(28),4169.
51Ge J, Jia Q, et al. Advanced Healthcare Materials,2016,5(6),665.
52Tang J, Kong B, et al. Advanced Materials,2013,25(45),6569.
53Wang H, Di J, Sun Y, Fu J, et al. Advanced Functional Materials,2015,25(34),5537.
54Wang H, Mukherjee S, et al. ACS Applied Materials & Interfaces,2017,9,18639.