智能响应型小分子探针在肿瘤诊疗方面的研究进展

doi:10.11896/cldb.21120202

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Abstract Since scientist Goodman and Gilmanat Yale University accidentally discovered that compound nitrogen mustard can suppress lymphoma in mice bearing lymphatic cancer, a new chapter in chemotherapy of cancers has been opened. To date, many drugs have been explored and successfully used for the diagnosis and treatment of tumors in clinics, but most of them encounter the problems such as poor biocompatibility, large side effect, and drug resistance. Therefore, it is urgent to develop novel theranostic drugs for effective cancer diagnosis and treatment. Recently, developing smart probes for tumor theranostics has gradually aroused great interest of scientists. Currently, a large number of stimuli-responsive probes for tumor imaging and treatment were designed and prepared choosing certain tumor microenvironment factors (acidic, environment, enzymes, redox special, hypoxia and signal molecule, etc) and exogenous fields (light, radiation and ultrasound, etc). Many researches have demonstrated these probes not only improve the theranostic efficacy, but also significantly reduce the toxic and side effect to the body, realizing the precise diagnosis and treatment of tumors. We mainly introduce the development of molecular probes for tumor theranostics in this paper, and summarize the application advances of smart probes in tumor theranostic in the past two years. Finally, a prospective for the future development direction and vision of stimulus-responsive probes in the field of cancer theranostics was also given.

Key words： smart probe stimuli-responsive materials tumor imaging tumor therapy theranostics

Published: Online: 2022-02-10

CLC number:

R445.9

Fund:Training Program of the Major Research Plan of the National Natural Science Foundation of China (91959123), National Natural Science Foundation of China (22077092), and Key Research and Development Program of Social Development of Jiangsu Province (BE2018655).

About author: Shuyue Ye received his Ph. D. degree from Soochow University in June 2021, and is currently a postdoctoral research fellow in University of Texas Southwestern Medical Center. He mainly focuses his research on Molecular Imaging under the guidance of Prof. Haibin Shi.

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	YE Shuyue
	FENG Yali
	SHI Haibin

Cite this article:

YE Shuyue,FENG Yali,SHI Haibin. Recent Advances in Smart Molecular Probes for Tumor Theranostics[J]. Materials Reports, 2022, 36(3): 21120202-15.

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http://www.mater-rep.com/EN/10.11896/cldb.21120202 OR http://www.mater-rep.com/EN/Y2022/V36/I3/21120202

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