普鲁士蓝基纳米粒子在癌症治疗及成像中的应用进展

Abstract
Figure/Table
References
Related Citation (2)

Download:

Full Text ( PDF ) (2137KB)
Export: BibTeX | EndNote (RIS)

Abstract Based on the pursuit of human health, aiming at improving the patients’ living standard, searching for better cancer treatments has always been the hot topic of research around the world. With the development of nanotechnology, more and more nanomaterials are used in tumor therapy. Photothermal therapy is a newly developed method in recent years which uses photothermal nanomaterials to destroy tumor cells with non-invasive management. Prussian blue is a coordination compound, and it has been approved by the FDA for the clinical treatment with reliable biological safety. Prussian blue nanoparticles has stable chemical properties, controllable shape and size sufficient synthetic raw materials and simple synthetic method. With good photothermal properties, it has been developed as a photothermal conversion agent. Prussian blue can also be used as a contrast agent in MRI, PA and ultrasound imaging, which opens up a new prospect for the tumor diagnosis and treatment. In this paper, we will introduce the application of prussian blue nanoparticles in cancer therapy from the aspects of photothermal therapy, tumor imaging and so on.

Key words： prussian blue photothermal therapy tumor imaging nanotechnology targeted therapy

Published: 08 January 2021

CLC number:

R318.08

Fund:This work was financially supported by the National Natural Science Foundation of China (81503020, 31600764), Scientific Research Funding Project of Liaoning Provincial Education Department (2019LJC04) and the Guidance Plan of Natural Science Foundation of Liaoning Province (2019-ZD-0459).

About author:: Xueyan Zhang graduated from Shenyang Pharmaceutical University and received her B.S. degree in July 2020. Her research focuses on new biomedical mate-rials.Zhaoxu Meng, associate professor of Shenyang Pharmaceutical University. He graduated from Harbin Engineering University in 2011 with a doctor's degree in materials science. After graduation, he went to Dalian Institute of Chemical Physics, Chinese Academy of Sciences for postdoctoral research. He joined Shenyang Pharmaceutical University in 2013. He was awarded the honorary titles of "ten thousand talents in Liaoning Province and top-notch talents in Shenyang". His research directions include biomedical materials, tissue repair and regeneration materials and new medical devices. As the project leader, As the project lea-der, he presided over one project of National Natural Science Foundation, two projects of Liaoning Provincial Department of education, one project of Shenyang Science and technology plan, and one fund of young and middle-aged development support program of Shenyang Pharmaceutical University. At present, more than 20 papers have been published in SCI journals, such as Mat. Sci. Eng C, J. Mater. Sci, Materials & Design, Colloids Surf. B, Small, Nanocsale, et al. He Lian obtained her Ph.D. degree in pharmaceutics from Shenyang Pharmaceutical University in 2014, and is now an associate professor in biomedical materials department of Medical Device College. Her research directions include bioactive materials and novel nanodrug delivery systems. As the project leader, she presided over one project of National Natural Science Foundation, one project of Liaoning Provincial Natural Science Foundation, one project of Liaoning Provincial Department of Education, and one special research fund of Shenyang Pharmaceutical University. At present, she has obtained 2 authorized patents and published more than 20 papers in SCI journals, such as Mat. Sci. Eng C, J. Contrl. Res, Mol. Pharm, Colloids Surf. B, Biomaterial Science, Macromol. Biosci, et al.

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	ZHANG Xueyan
	MENG Zhaoxu
	LIAN He

Cite this article:

ZHANG Xueyan,MENG Zhaoxu,LIAN He. Application Progress of Prussian Blue Nanoparticles in Cancer Therapy and Imaging[J]. Materials Reports, 2020, 34(Z2): 95-98.

URL:

http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2020/V34/IZ2/95

1 周亚丹, 朱江. 中华超声影像学杂志, 2019(8), 733.
2 郭一霏. 多孔磁性普鲁士蓝复合材料的合成研究. 硕士学位论文, 华东师范大学, 2017.
3 Gautam M, Poudel K, Yong C S, et al. International Journal of Pharmaceutics, 2018,549(1-2),31.
4 Fu G L, Liu W, Feng S S, et al. Chemical Communications, 2012, 48(94), 11567.
5 Yao J, Wang L V. Current Opinion in Chemical Biology, 2018, 45,104.
6 Yan L, Zhou X, Zheng Y, et al. Clinics, 2019, 74,e715.
7 Liu J, Pan Y, Li M, et al. Big Data Mining and Analytics, 2018, 1(1), 1.
8 Houbois C P, Thavendiranathan P, Wintersperger B J, et al. Journal of Thoracic Imaging, 2020, 35(1), 12.
9 Yang K, Feng L Z, Liu Z, et al. Advanced Drug Delivery Reviews, 2016, 105, 228.
10 Wu J, Williams G R, Niu S, et al. Theranostics, 2020, 10(2), 841.
11 Su Y Y, Yao H, Zhao S, et al. Journal of Colloid and Interface Science, 2018, 512, 439.
12 Zhang L, Zhang Y, Xue Y N, et al. Advanced Materials, 2019, 31, 8.
13 Lei Y T, Zeng L, Xie S Q, et al. Chemical Biology & Drug Design, 2020, 95(3), 320.
14 Xu W J, Qian J M, Hou G H, et al. Acta Biomaterials, 2019, 83, 400.
15 Ming J, Zhang J J, Shi Y R, et al. Nanoscale, 2020, 12(6), 3916.
16 刘迪. 光热治疗联合免疫治疗复合制剂抗肿瘤活性研究. 硕士学位论文,苏州大学, 2016.
17 陈华健. 肿瘤热化疗用普鲁士蓝纳米载药颗粒的构建及性能表征. 硕士学位论文,合肥工业大学, 2018.
18 Arindam Bhattacharjee, áron Szabó, Tamás Csizmadia, et al. Journal of Genetics and Genomics, 2019, 46(4), 157.
19 Liu B, Wang W M, Fan J L, et al. Biomaterials, 2019,217,119301.
20 Liang X L, Deng Z J, Jing L J,et al. Chemical Communications, 2013, 49(94), 11029.
21 Tian W, Su Y Y, Tian Y, et al. Advanced Science, 2017, 4(3).
22 Yang F, Hu S L, Zhang Y, et al. Advanced Materials, 2012, 24(38), 5205.
23 徐燕军. 普鲁士蓝纳米粒的设计合成及在肿瘤多模式显像和热疗中的应用. 博士学位论文, 上海交通大学, 2018.
24 Feng S S, Wang J, Liang X, et al. Journal of Nanoscience and Nanotechnology, 2016, 16(3), 2184.
25 Shokouhimehr M, Soehnlen E S, Khitrin A, et al. Inorganic Chemistry Communications, 2010, 13(1), 58.
26 Li Z Z, Zeng Y Y, Zhang D, et al. Journal of Materials Chemistry B, 2014, 2(23), 3686.
27 Liu Y X, Guo Q W, Zhu X, et al. Advanced Functional Materials, 2016, 26(28), 5120.
28 Zhang N, Cai X J, Gao W, et al. Theranostics, 2016, 6(3), 404.
29 康宝江. 基于普鲁士蓝多功能纳米粒子的制备及其应用研究. 硕士学位论文, 长春理工大学, 2019.
30 Li J H, Zhang F S, Hu Z G, et al. Advanced Healthcare Materials, 2017, 6(14), 170005.
31 Kim H, Chung K, Lee S J, et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology, 2016, 8(1), 23.
32 Kue C S, Kamkaew A, Burgess K, et al. Medicinal Research Reviews, 2016, 36(3), 494.
33 尚婷婷. 载普鲁士蓝靶向纳米复合物多模态显像及综合治疗裸鼠乳腺癌的实验研究.博士学位论文, 重庆医科大学, 2017.
34 Jing L J, Shao S M, Wang Y, et al. Theranostics, 2016, 6(1), 40.
35 Mottaghitalab F, Farokhi M, Fatahi Y, et al. Journal of Controlled Release, 2019, 295, 250.
36 Dou Y, Li X, Yang W T, et al. ACS Applied Materials & Interfaces, 2017, 9(2), 1263.