| POLYMERS AND POLYMER MATRIX COMPOSITES |
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| Recent Progress in Nanocarriers for Intracellular Protein Drug Delivery |
| JIANG Jiamin, LI Panpan, FANG Bin, DU Wei, BAI Hua*, PENG Bo, LI Lin
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| Frontiers Science Center for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an 710072, China |
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Abstract Nowadays, many diseases like cancer, cardiovascular, cerebrovascular diseases, and central nervous system pathology are becoming more and more important issues that can endanger human health. Due to the low-specificity, the traditional small-molecule drugs can easily affect normal cells other than tumor cells during the treatment process, thereby causing toxic and side effects on the body. Protein as a drug has higher biocompatibility and specificity compared with traditional small molecule drugs. However, its special molecular structure and biochemical properties make protein drugs easily inactivated in complex biological environments. These problems limit the application of protein drugs in biomedicine. Therefore, it is particularly important to find an ideal drug delivery system to make up for the deficiencies of the drug itself, and to help the drug work effectively in the lesion area. In order to solve this problem, the industry has developed various nano drug carriers with different functions, such as polymer nano carriers, lipid nano carriers, inorganic nano carriers, etc. This review comprehensively summarizes the intracellular delivery strategies of protein drugs based on different carriers. What's more, the materials' design methods, mechanism of action, and potential applications in living or in vivo will be discussed in detail. Finally, we prospected the application of the new-generation drug delivery system in the field.
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Published: 14 July 2021
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| Fund:This work was financially supported by the National Natural Science Foundation of China (81672508), Shaanxi Provincial Natural Science Fundamental Research Program (2019JM-016, 2019JM-130). |
About author:: Jiamin Jiang, received her B. S. degree from Xiangtan University in June 2019. She is currently a post graduate student at the School of Chemistry and Chemical Engineering of Northwestern Polytechnic University. She studies in the organic/biomedical photonics research group in the charge of Prof. Lin Li. Her main research has focused on protein regulation of fluorescent dyes.
Hua Bai, received her Ph.D. degree in toxicology from the Fourth Military Medical University (China) in 2011. She is currently a full assistant professor in Northwestern Polytechnical University (NPU). Her research interests are mitochondrial dynamics and quality control in diseases associated with mitochondrial dsyfunction such as neurodegeneration. She has published over 20 papers on Antioxidants & Redox Signaling, Free Radical Biology & Med.,Carcinogenesis and so on.
Lin Li, received his Ph.D. (Chemistry) from Anhui University (China) in 2009 and obtained postdoctoral training as a research fellow in National University of Singapore (Chemical Biology, 2009—2014) in Shao Q. Yao’s lab. In 2015, he got his current professor position in Nanjing Tech University as a member of “Thousand Young Talents Program of China”. Now, he is a professor of Institute of Flexible Electronics (IFE), Northwestern Polytechnical University (NPU), China. His research focuses on the synthetic small-molecule indicators for mitochondrial biomarkers identification/detection/regulation. He has published over 170 papers on Accounts of Chemical Research, Nature Communications, Journal of the American Chemical Society, Angewandte Chemie International Edition and so on. |
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2021, Vol. 35 
