Materials Reports  2020, Vol. 34 Issue (Z2): 91-94 |
| INORGANIC MATERIALS AND CERAMIC MATRIX COMPOSITES |
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| Preparation of Hollow Silica Microspheres Using Nano Calcium Carbonate as Template |
| ZHANG Shuo
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| Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310020,China |
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Abstract Silica hollow microspheres have received extensive attention from researchers because of their potentially important applications in catalysis, biomolecular packaging, drug delivery, and gene delivery. In this study, self-made nano-calcium carbonate was used as a template, and ethyl orthosilicate was used as a silicon source to prepare hollow silica microspheres with complete structure. The results showed that the nano-calcium carbonate prepared with a calcium hydroxide solution of 0.15% concentration had complete spherical structure, with the increase of cal-cium hydroxide concentration, calcium carbonate begins to transform from spherical structure to massive or fibrous structure in the form of calcite crystals. Ethyl orthosilicate is used as a silicon source to form monomers through hydrolysis. Adjusting the pH value allows the hydrolysate to nucleate and grow on the nano-calcium carbonate template and form a three-dimensional network skeleton through polycondensation. After removing the template and drying, the structure is intact hollow silica microspheres.
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Published: 08 January 2021
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| About author:: Shuo Zhang received her bachelor of science degree from Wannan Medical College in 2014. Now he is a pharmacist at the Sir Run Run Shaw Hospital, Zhejiang University School of Medicine. Her research focuses on drug carriers. |
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1 Frans D, Paul M, Jason S,et al. Chemical Engineering Science, 2011, 66(16), 3641.
2 He J, Li X F, Evans D G, et al. Journal of Molecular Catalysis B Enzymatic, 2000, 11(1), 45.
3 Shruti, Rawal, Mayur, et al.Journal of Controlled Release: Official Journal of the Controlled Release Society, 2019, 301, 109.
4 Zhou Y X, Quan G L, Wu Q L, et al. Acta Pharmaceutica Sinica B, 2018, 8(2), 167.
5 唐玥. 中国药科大学学报, 2012, 43(6), 567.
6 崔妍, 汪顺浩, 潘雪婷, 等. 生物加工过程, 2018, 16(1), 49.
7 Jafari S, Derakhshankhah H, Alaei L, et al. Biomedicine & Pharmacotherapy, 2019, 109, 1100.
8 安璐, 张崇琨, 胡鹤, 等.上海师范大学学报, 2012, 41(4), 432.
9 Kim S S, Zhang W, Pinnavaia T J.Science, 1998, 282(5392), 1302.
10 Zhu J, Tang J, Zhao L, et al.Small, 2010, 6(2), 276.
11 王晓艳, 黄玉玲, 刘文波, 等. 分子科学学报, 2013, 29(4), 320.
12 Dorcheh A S, Abbasi M H.Journal of Materials Processing Technology, 2008, 199(1-3), 20.
13 Scherer G W, Smith D M.Journal of Non-Crystalline Solids, 1995, 189(3), 197. |
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