Fe-Mn合金在生物医学方面的应用及前景

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Abstract After the implantation operation, the biodegradable stent provides a certain supporting effect for the blood vessels during vasculars’ repairing, which is expected to convert into some non-toxic degradation products by interacting with the internal environment and then absorbed or excreted by the body within a certain time when the repairing is done. Therefore, to be degradable stents, strict requirements have been placed on the mechanical properties, corrosion resistance, degradation characteristics, biocompatibility, and other properities of metal materials.
In recent years, iron-based alloys, as degradable metal materials, have become a new research hotspot in biomedical field. Since pure iron is one of the essential trace elements in the human body, and excellent in mechanical properties, corrosion resistance, degradation characteristics, biological properties and processing formability, it is potential to be iron-based alloys as biomedical degradable materials.
However, pure iron has a slow degradation rate, which is one of the major problems that hinder its biomedical application. Alloying is expected to improve its degradation properties, mechanical properties, eventually as well as the overall performance of iron-based materials. While increa-sing degradation rate, iron-based materials should also be required to ensure adequate mechanical properties to support the blood vessels. And better mechanical properties, thinner stent as well as lighter mass, can ensure a shorter degradation time, which provides less degradation pro-ducts and toxic to the human body.
This paper reviews the research status of iron-based alloys as scaffold materials, as well as the mechanical properties, corrosion, degradation properties and in vitro cell compatibility of iron-manganese alloys. Meanwhile the present research status of ferromanganese alloys in biodegradable stents and key issues to be solved are mainly focused, as well as several potential solutions.

Key words： biomedical Fe-Mn alloy powder metallurgy mechanical properties degradation performance

Published: 25 November 2019

CLC number:

R318.08

About author:: Yuling Liu received her B.E. degree in material processing and control engineering from Heifei University in 2017. She is currently pursuing her M.D. at the School of Material Science and Engineering, East China University of Science and Technology under the supervision of A.P. Xiuqing Zhang. Her research has focused on biodegradable iron-manganese alloy.
Xiuqing Zhang, associate professor of East China University of Science and Technology, Master’s tutor. He obtained her Ph.D. degree from Shanghai Jiaotong University at 2006. After graduation, he worked at East China University of Science and Technology. Among 2014.7—2015.2, he went to Rensselaer Polytechnic Institute as a visiting scholar. He has published more than 60 papers in academic journals, and applied for 11 national invention patents. His team’s main research interests include: surface engineering technology, advanced manufacturing technology, material synthesis, structure and performance research, new alloy materials, material corrosion, wear and protection, nanomaterial preparation, application and engineering, and development of metal matrix composites, etc. Responsible for completing more than 10 scientific research projects, and has trained more than 20 masters.

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Cite this article:

LIU Yuling,ZHANG Xiuqing. Application and Prospect of Biomedical Fe-Mn Alloy[J]. Materials Reports, 2019, 33(Z2): 331-335.

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http://www.mater-rep.com/EN/ OR http://www.mater-rep.com/EN/Y2019/V33/IZ2/331

1 Zheng Y F, Gu X N, Witte F. Materials Science and Engineering R Reports,2014,77,1.
2 郑玉峰,刘彬,顾雪楠.材料导报:综述篇,2009,23(1),1.
3 Peuster M, Hesse C, Schloo T, et al. Biomaterials,2006,27(28),4955.
4 何进.基于电沉积的可生物降解铁合金的研究.博士学位论文,西北工业大学,2017.
5 Schomig A. Circulation,1994,90(6),2716.
6 Waksman R. Journal of Interventional Cardiology,2006,19(5),414.
7 Serruys P W, Kutryk M J B, Ong A T L. New England Journal of Medicine,2006,354(5),483.
8 郑玉峰,杨宏韬.金属学报,2017,53(10),1227.
9 Bowen P K, Shearier E R, Zhao S, et al. Advanced Healthcare Materials,2016,5(10),1121.
10 Erinc M, Sillekens W H, Mannens R, et al. In: Mangnesium Technology 2009. San Francisco, USA,2009.
11 Andrews N C. The New England Journal of Medicine,1999,341(26),1986.
12 Hermawan H, Dubé D, Mantovani D. Acta Biomaterialia,2009,6(5),1693.
13 Mani G, Feldman M D, Patel D, et al. Biomaterials,2007,28(9),1689.
14 Moravej M, Purnama A, Fiset M, et al. Acta Biomaterialia,2010,6(5),1843.
15 Cheng J, Liu B, Wu Y H, et al. Journal of Materials Science & Technology,2013,29(7),619.
16 Nie F L, Zheng Y F, Wei S C, et al. Biomedical Materials,2010,5(6),1.
17 Lin W J, Zhang G, Cao P, et al. Journal of Biomedical Materials Research Part B: Applied Biomaterials,2015,103(4),764.
18 Peuster M, Wohlsein P, Brügmann M, et al. Heart,2001,86(5),563.
19 Zhu S, Huang N, Xu L, et al. Materials Science & Engineering: C (Materials for Biological Applications),2009,29(5),1589.
20 Mueller P P, May T, Perz A, et al. Biomaterials,2006,27(10),2193.
21 Zhu X M, Zhang Y S. Corrosion,1998,54,3.
22 徐文利,陆喜,谭丽丽,等.金属学报,2011(10),1312.
23 Erikson K M, Syversen T, Aschner J L, et al. Environ Toxicol Pharma-col,2005,19(3),415.
24 张成燕,宋帆,王珊玲,等.金属学报,2015,51(2),201.
25 Revie R W, Uhlig H H. Corrosion and corrosion control: An introduction to corrosion science and engineering (Fourth edition),John Wiley & Sons, Inc., USA,2008,pp.30.
26 Schinhammer M, Hänzi A C, Löffler J F, et al. Acta Biomaterialia,2010,6(5),1705.
27 Beattie J H, Avenell A. Nutrition Research Reviews,1992,5(1),167.
28 Hermawan H, Dubé D, Mantovani D. Journal of Biomedical Materials Research Part A,2010,93A(1),1.
29 Heiden M, Walker E, Nauman E, et al. Journal of Biomedical Materials Research Part A,2015,103(1),185.
30 apek J, Kubásek J, Vojtěch D, et al. Materials Science and Engineering C: Materials for Biological Applications,2016,58,900.
31 Chou D T, Wells D, Hong D, et al. Acta Biomaterialia,2013,9(10),8593.
32 Hermawan H, Purnama A, Dube D, et al. Acta Biomaterialia,2010,6(5),1852.
33 Heiden M, Kustas A, Chaput K, et al. Journal of Biomedical Materials Research Part A,2015,103(2),738.
34 Hermawan H, Alamdari H, Mantovani D, et al. Powder Metallurgy,2008,51(1),38.
35 Zhang Q, Cao P. Materials Chemistry and Physics,2015,163,394.
36 Drynda A, Hassel T, Bach F W, et al. Journal of Biomedical Materials Research Part B: Applied Biomaterials,2015,103(3),649.
37 Pennington J A. Food Additives and Contaminants,1991,8(1),97.
38 Song G. Corrosion Science,2007,49(4),1696.
39 Supannee S, Ravin J, Hazel E, et al. British Journal of Nutrition,2004,91(3),403.
40 郭芝斌.Fe-Mn-Si系形状记忆合金形状记忆效应及耐腐蚀性能的研究.博士学位论文,西南石油大学,2016.
41 Liu B, Zheng Y F, Ruan L Q. Materials Letters,2011,65(3),540.
42 陈泳.甘肃科技,2005,21(5),194.
43 毛丽贺,王玉林,万怡灶,等.金属热处理,2009,34(10),19.
44 王琳霞.塑料科技,2002(1),37.
45 Hermosilla D, Cortijo M, Huang C P. Chemical Engineering Journal,2009,155(3),637.
46 Waksman R, Pakala R, Yaffour R, et al. Journal of Interventional Car-diology,2008,21(1),15.
47 Hermawan H, Dubé D, Mantovani D. Advanced Materials Research,2007,15-17,107.
48 Liu B, Zheng Y F. Acta Biomaterialia,2011,7(3),1407.
49 Schinhammer M, Gerber I, Hänzi A C, et al. Materials Science and Engineering C,2013,33(2),782.
50 Vojtech D, Kubasek J, Capek J, et al. Materiali in Tehnologije,2015,49(6),877.
51 Sing N B, Mostavan A, Hamzah E, et al. Journal of Biomedical Materials Research Part B: Applied Biomaterials,2015,103(3),572.