聚氨基酸材料的研究进展

doi:10.11896/cldb.21080287

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Abstract Synthetic polypeptides from the ring-opening polymerization (ROP) of amino acid N-carboxyanhydrides (NCAs) are a type of natural protein mimics. The unique features of these synthetic polypeptides, including the chemical diversity of amino acids, the unique self-assembly structures and conformation transition, and the desired biological activity and good biocompatibility, enable their broad biological applications. The new ROP method represented by auto-accelerated cooperative covalent polymerization provides a new direction for the efficient preparation of polypeptide materials. Additionally, polypeptides with α-helical or β-sheet conformations can be used as building blocks for self-assembly, forming unique chiral and nanomaterials, which benefit the research on structural and functional biomimetics and biomedical applications. The conformational transitions of polypeptide materials, triggered by pH, light, heat, redox, etc, are always accompanied by the changes in their physical pro-perties (such as hydrophobicity), chemical structures (such as charge reversion), and biological activity (such as cytotoxicity), offering a new strategy for materials to adapt to the changes of biological microenvironment and targeted delivery. As a result, polypeptide materials have shown great potentials in biological applications such as antibacterial, antifouling, antitumor, gene delivery, tissue engineering, and immune regulation. This review offers a retrospection of the research process of synthetic polypeptides materials, which covered advanced preparation methods, assembly structure, conformation transition, and biological applications. In order to provide reference for the further research of synthetic polypeptides, we also raised some important questions for this field.

Key words： polypeptides ring-opening polymerization self-assembly conformational transition biomaterials

Published: Online: 2022-02-10

CLC number:	TB34
	O63

Fund:National Natural Science Foundation of China (51873213).

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	Articles by authors
	YANG Fangping
	SONG Ziyuan
	YIN Lichen
	TANG Haoyu
	CHENG Jianjun

Cite this article:

YANG Fangping,SONG Ziyuan,YIN Lichen, et al. Research Progress of Synthetic Polypeptides Materials[J]. Materials Reports, 2022, 36(3): 21080287-18.

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http://www.mater-rep.com/EN/10.11896/cldb.21080287 OR http://www.mater-rep.com/EN/Y2022/V36/I3/21080287

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