生理pH下可控释放胰岛素的温度/葡萄糖双响应可注射复合水凝胶

doi:10.11896/cldb.21040234

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Abstract The Alg-g-PNA/Alg-g-PNIPAM injectable composite hydrogel system, which can respond to glucose at physiological pH, is successfully prepared in this work. The temperature- and glucose-responsive properties of the composite system are studied. The results show that the composite system is in the sol state at 10 ℃, and turns into the gel state at 37 ℃. The low critical solution temperature (LCST) of the composite system increases gradually with the increase of glucose concentration at pH=7.4, and the glucose response is good. The hydrodynamic properties of the composite system are investigated. The results show that the composite system has good thermal reversibility and self-healing property. Finally, the in vitro drug release performance of the composite system is investigated. The results show that the cumulative insulin release percentages from the composite system at high glucose concentrations are much higher than that at low glucose concentrations within 48 h. And the composite gel can also adapt to the circulation between high blood sugar and normal blood sugar. The composite system can realize the sol-gel phase transition only through simple ambient temperature or glucose concentration stimulation and can respond to blood glucose timely at physiological temperature and pH, which provides a new strategy for the development of self-regulating insulin delivery system based on blood glucose response.

Key words： injectable hydrogel graft copolymer blood glucose phenylboronic acid insulin self-regulating delivery system

Published: Online: 2022-02-10

CLC number:	TB332
	TQ317

Fund:National Natural Science Foundation of China (22078202, 21991101).

About author: Danna Hu is M. S. Candidate of Sichuan University, and mainly focused on research of functional polymer materials for intelligent controlled release. She received her bachelor's degree of Sichuan University in 2018 and was recommended to be a master's student. She won several national and university-level honors such as National Scholarship and National Encouragement Scholarship during her undergraduate and postgraduate studies.

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	HU Danna
	JU Xiaojie
	XIE Rui
	WANG Wei
	LIU Zhuang
	CHU Liangyin

Cite this article:

HU Danna,JU Xiaojie,XIE Rui, et al. Injectable Temperature- and Glucose-responsive Composite Hydrogels for Controlled Release of Insulin at Physiological pH[J]. Materials Reports, 2022, 36(3): 21040234-7.

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http://www.mater-rep.com/EN/10.11896/cldb.21040234 OR http://www.mater-rep.com/EN/Y2022/V36/I3/21040234

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