聚羟基脂肪酸酯(PHAs)基止血材料研究进展

doi:10.11896/cldb.21010218

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Abstract During accidents, natural disasters and war, the body of human may suffer serious physical trauma, which will lead uncontrollable massive blood loss. This may further result in ischemic shock and death in the injured. Therefore, fast hemostasis of wound is the key to improve the survival rate of the injured. Fast hemostasis is generally based on using hemostatic materials. Polyhydroxyalkanoates (PHAs), a natural polymer compound, has good biocompatibility, biodegradability and modifying properties. The degradation products of PHAs can also promote the proliferation and differentiation of cells, which can further facilitate healing of wound. Hence PHAs is a good matter of developing hemostatic materials and has attracted extensive attention from biomedical materials researchers. However, PHAs-based materials still have some shortcomings, such as poor toughness, low antibacterial and coagulation performance. Before developing PHAs-based hemostatic materials, the toughness, antibacterial capacity and coagulation performance need to be improved. This review summarizes the research progress of PHAs-based hemostatic materials in recent years, which may provide effective methods and instructions for researching and developing the PHAs-based hemostatic materials. The successful development of PHAs-based hemostatic materials with great socioeconomic value will have significance for emergency of military and sustainable development of mankind.

Key words： polyhydroxyalkanoates mechanical property hemostatic material coagulation antibacterial

Published: 10 February 2023 Online: 2023-02-23

CLC number:

R318.08

Fund:The Shenzhen Fund in Special Foundation for Guiding Local Science and Technology Development of the Central Government (2021Szvup001), the Key Program of Marine Economy Development (Six Marine Industries) Special Foundation of Department of Natural Resources of Guangdong Province (GDNRC［2020］034), the Shenzhen Basic Research Project (JCYJ20170815153143221, JCYJ202000109144604020), the China Postdoctoral Science Foundation (2021M690247), and the IER Innovation Foundation (HT-JD-CXY-201902, HT-JD-CXY-201907).

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	Articles by authors
	WU Yuandong
	ZHENG Weishuang
	LI Yuanju
	DU Beining
	ZHANG Xingru
	LI Jialong
	YU Shengyang
	XIAO Yinan
	LAI Chen
	SHENG Liyuan
	HUANG Yi

Cite this article:

WU Yuandong,ZHENG Weishuang,LI Yuanju, et al. Research Progress on Polyhydroxyalkanoates (PHAs)-based Hemostatic Materials[J]. Materials Reports, 2023, 37(3): 21010218-9.

URL:

http://www.mater-rep.com/EN/10.11896/cldb.21010218 OR http://www.mater-rep.com/EN/Y2023/V37/I3/21010218

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