细菌感染微环境响应性高分子材料用于细菌感染性疾病的治疗

doi:10.11896/cldb.201901001

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Abstract Since the discovery of penicillin in 1928, the application of antibiotics has greatly reduced the morbidity and mortality of bacterial infectious di-seases, and numerous lives are survived from bacterial infection. However, with the widespread use and abuse of antibiotics, antimicrobial resistance has become a global public health issue. In addition, there are several problems that traditional antibiotic therapies encounter. Specifi-cally speaking, the antibiotics are rapidly metabolized and excreted from body after administration, only a few drugs reach the infected site and the bioavailability was low. In this case, high doses and long period treatments are required in clinical application, which lead to notable side effects. Besides, the poor therapeutic effect of antibiotics against biofilm infections and intracellular infections is also a pressing issue, leading to chronic infections and recurrent infections.
In view of the problems existing in the traditional antibiotic delivery mode, the delivery of antibiotics by nanoparticles is proposed and shows great potential in the treatment of bacterial infection, which can improve the solubility of poorly soluble drugs, improve the pharmacokinetics and biodistribution of antibiotics, and overcome the tissue and cell barriers. Inspired by the fact that the physiological and physical microenvironment of bacterial infection sites is different from normal tissues, polymeric nanoparticles, that are responsive to the unique infectious microenvironments, have been developed to deliver antibiotics. These strategies remarkably improve the bioavailability and biodistribution of antibiotics, enhance the therapeutic efficacy of antibiotics against intracellular and biofilm infections, as well as attenuate the side effects.
However, the delivery of antibiotics by nanoparticles shows limitations in the treatments of drug-resistant bacteria and especially for multidrug-resistant bacteria. Aiming at the problems of antibiotic resistance, antimicrobial peptides and their analogues have attracted extensive attention worldwide, since they exhibit broad-spectrum antibacterial activity with the less like-hood to develop drug resistance. Nevertheless, the cytotoxicity of these antibacterial agents hinders their clinical applications. For the sake of solving this problem, researchers designed responsive antimicrobial polymers that exhibited low toxicity in normal tissues, and transformed to active form to effectively kill drug-resistant bacteria when triggered by the acid infectious environment or bacterial enzymes in the infectious environment.
In this review, we gave a brief introduction on the existing issues on traditional antimicrobial therapy, and an overview and current perspectives on the development infection-microenvironment responsive polymeric nanoparticles as carriers of antibiotics and the infection-responsive antimicrobial polymers for the treatment of bacterial infectious diseases over the past decade.

Key words： bacterial infection microenvironment responsiveness nanoparticles antimicrobial polymers drug-resistant bacteria antibiotic

Published: 24 January 2019

CLC number:	TB34
	O63

Fund:This work was financially supported by the Natural Science Foundation of China (51873070,U1801252), Natural Science Foundation of Guangdong Province, China (2018A030313110), Science and Technology Program of Guangzhou (201804020060), Young 1000 Talents Global Recruitment Program of China, and the Fundamental Research Funds for the Central Universities.

About author:: Yingjun Wang, Professor of Biomaterials and Biomedi-cal Engineering. She currently serves as the Director of National Engineering Research Center for Tissue Restoration and Reconstruction and the Fellow of Biomaterials Science and Engineering (FBSE) of International Union. Prof. Wang devoted herself to biomaterial for more than 3 decades, and she has developed a wide variety of the new generation biomedical materials and promoted their commercialization, especially on biomimetic materials for bone restoration and tackled the problem of bone regeneration for load-bearing applications.Menghua Xiong received his B.S. and Ph.D. degrees in Polymer Science and Engineering from University of Science and Technology of China in 2007 and 2013, respectively. He was a postdoctoral associate at University of Illinois at Urbana-Champaign during 2013 to 2017. In 2018, he became a professor in the School of Biomedi-cal Science and Engineering at South China University of Technology. His research interests include nanomaterials, polymer chemistry, biomaterials.

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	WANG Yingjun
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Cite this article:

WANG Yingjun,HUANG Xuelian,CHEN Junjian, et al. Bacterial Infection-microenvironment Responsive Polymeric Materials for the Treatment of Bacterial Infectious Diseases: a Review[J]. Materials Reports, 2019, 33(1): 5-15.

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http://www.mater-rep.com/EN/10.11896/cldb.201901001 OR http://www.mater-rep.com/EN/Y2019/V33/I1/5

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