新型可生物降解的组织可黏附材料的合成与表征

doi:10.11896/cldb.20120176

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Abstract This paper designed and synthesized a kind of polymerizable and curable tissue adhesive materials with good biodegradability. The material is a monomer molecule before use, and it is liquid at room temperature. The monomer structure is composed of monomeric oligolactic acid (OLA) fragments and cyanoacrylate (CA) functional groups. When coming into contact with body tissues, monomers can undergo intermolecular polymerization through CA functional groups to form comb polymers and produce adhesion. The OLA side chain structure in the polymer can give good biocompatibility and degradability. Two monomers, OLA₄-CA and OLA₄B-CA, with carboxyl or benzyl groups at the ends of OLA were synthesized. The chemical structure of the monomers was determined by ¹H nuclear magnetic resonance spectroscopy, and the shear tensile strength and curing times were used to characterize tissue adhesion. Polymer molecular weight and polymer degradation in vivo and in vitro was analyzed by gel permeation chromatography, with biocompatibility determined using implantation tests. In addition, the bacteriostatic properties of the material were tested by inhibition zone test in vitro. The results show that the target monomer is synthesized successfully and the synthesized monomer polymerized and solidified within 3 min following tissue contact and produced effective adhesion.Degradation of the polymer was related to the terminal carboxyl structure of the side chain OLA segment, with the preferred OLA₄-CA polymer completely degraded and absorbed within 12 h after implantation in a mouse model; this indicated good biocompatibility. In addition, the in vitro inhibition zone test showed concentration-dependent antibacterial activity of material. This polymerizable material is expected to be used in the development of new wound dressings and tissue adhesive materials.

Key words： oligo-lactic acid cyanoacrylate antibacterial brushed copolymer

Published: Online: 2022-02-10

CLC number:

R318.08

Fund:Beijing Natural Science Foundation (7202146).

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	Articles by authors
	LIU Jimin
	ZHU Huimin
	PAN Jian
	SONG Liya
	LIU Shan
	HUA Yabing
	SHI Rui
	XU Liang

Cite this article:

LIU Jimin,ZHU Huimin,PAN Jian, et al. Synthesis and Characterization of New Biodegradable Tissue Adhesive Materials[J]. Materials Reports, 2022, 36(3): 20120176-6.

URL:

http://www.mater-rep.com/EN/10.11896/cldb.20120176 OR http://www.mater-rep.com/EN/Y2022/V36/I3/20120176

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