尼龙66/纳米羟基磷灰石复合纤维膜的制备及骨缺损修复性能评价

doi:10.11896/cldb.19060030

Abstract
Figure/Table
References
Related Citation (15)

Download:

Full Text ( PDF ) (8597KB)
Export: BibTeX | EndNote (RIS)

Abstract PA66/HAP composite fiber membranes with different HAP contents were prepared by electrospinning in order to prevent fibrous tissue and induce bone growth. The effects of HAP concentration on the morphology, fiber diameter, crystallinity and biocompatibility of bone guiding membranes were studied. The results showed that uniform PA66/HAP composite fiber membrane can be obtained by electrospinning, and the fiber diameter of PA66/HAP composite fiber membranes decreased first and then increased with the increase of HAP content. DSC results showed that the addition of HAP promoted the growth of β-type crystals in PA66 fiber membranes, and the crystallinity of PA66/HAP composite fiber membranes decreased with the increase of HAP content, which increased the flexibility of the fiber membranes. XRD results showed that PA66/HAP composite fiber membranes retained the characteristics of PA66 and HAP. Cytotoxicity results showed that the fibrous membrane had no cytotoxi-city, and HAP could promote cell proliferation significantly. Fiber membranes implanted in animals did not cause inflammation and had good implantation safety. Animal experiments showed that PA66/HAP composite fiber membrane can effectively block the growth of fibrous tissue and guide bone growth. In conclusion, PA66/HAP composite fiber membranes has good application prospects in the field of bone defect repair.

Key words： nylon 66 nano-hydroxyapatite composite fiber membrane electrospinning biocompatibility

Published: 29 May 2020

CLC number:

Q819

About author:: Xiang Yu, associate professor, has taught in School of Materials and Chemical Engineering of Henan University of Engineering since september 2010. He received doctor of science degree from Zhengzhou University in June 2010. He focuses his researches on polymer composites and 3D printing materials.
Xiaolong Lu received his bachelor degree in June 2017 from Henan University of Engineering. Since September 2017, he has been studying for M.S. degree in School of Material and Engineering, Henan Polytechnic University, focusing on the research of functional polymer materials and photocatalysis.

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	YU Xiang
	GUI Jiuqing
	ZHANG Xueyin
	YAN Liang
	LU Xiaolong

Cite this article:

YU Xiang,GUI Jiuqing,ZHANG Xueyin, et al. Preparation of Nylon 66/Nano-hydroxyapatite Composite Fiber Membrane and Evaluation of Bone Defect Repair Performance[J]. Materials Reports, 2020, 34(12): 12185-12190.

URL:

http://www.mater-rep.com/EN/10.11896/cldb.19060030 OR http://www.mater-rep.com/EN/Y2020/V34/I12/12185

1 Wang W, Yeung K W K. Bioactive Materials,2017,2(4),224.
2 Stafford P R, Norris B L. Injury,2010,41,S72.
3 Nandi S K, Roy S, Mukherjee P, et al. Indian Journal of Medical Reseach,2010,132(1),15.
4 Rozbruch S R, Weitzman A M, Watson J T, et al. Journal of Orthopaedic Trauma,2006,20(3),194.
5 Rozbruch S R, Pugsley J S, Fragomen A T, et al. Journal of Orthopaedic Trauma,2008,22(2),88.
6 Kim K H, Jeong L, Park H N, et al. Journal of biotechnology,2005,120(3),327.
7 Hong K S, Kim E C, Bang S H, et al. Journal of Biomedical Materials Research Part A,2010,94(4),1187.
8 Ma S, Chen Z, Qiao F, et al. Journal of Dentistry,2014,42(12),1603.
9 Kellomäki M, Niiranen H, Puumanen K, et al. Biomaterials,2000,21(24),2495.
10 Davim J P, Silva L R, Festas A, et al. Materials & Design,2009,30(2),228.
11 Guan X, Zheng G, Dai K, et al. ACS Applied Materials & Interfaces,2016,8(22),14150.
12 Xu X, Li B, Lu H, et al. Applied Surface Science,2007,254(5),1456.
13 Szczes' A, Hośysz L, Chibowski E. Advances in Colloid and Interface Science,2017,249,321.
14 Agrawal K, Singh G, Puri D, et al. Journal of Minerals and Materials Characterization and Engineering,2011,10(8),727.
15 Bai H, Walsh F, Gludovatz B, et al. Advanced Materials,2016,28(1),50.
16 Cox S C, Thornby J A, Gibbons G J, et al. Materials Science and Engineering: C,2015,47,237.
17 Woodard J R, Hilldore A J, Lan S K, et al. Biomaterials,2007,28(1),45.
18 Xiong Y, Ren C, Zhang B, et al. International Journal of Nanomedicine,2014,9,485.
19 Zhang X, Li Y B, Zuo Y, et al. Composites Part A: Applied Science and Manufacturing,2007,38(3),843.
20 Zhang X, Li Y, Lv G, et al. Polymer Degradation and Stability,2006,91(5),1202.
21 Qu Y, Wang P, Man Y, et al. International Journal of Nanomedicine,2010,5,429.
22 Li J, Zuo Y, Cheng X, et al. Journal of Materials Science: Materials in Medicine,2008,20(5),1031.
23 Fong H, Chun L, Reneker D H. Polymer,1999,40(16),4585.
24 Wang Z M, Bai S H, Zhang X X, et al. Acta Materiae Compositae Sinica,2010,27(1),12(in Chinese).
王志苗,白世河,张兴祥,等.复合材料学报,2010,27(1),12.
25 Zhang X, Li Y B, Lv G Y, et al. Journal of Functional Materials,2005,36(6),896(in Chinese).
张翔,李玉宝,吕国玉,等.功能材料,2005,36(6),896.
26 Zuo Y, Li Y B, Wei J, et al. Journal of Functional Materials,2004,35(4),513(in Chinese).
左奕,李玉宝,魏杰,等.功能材料,2004,35(4),513.
27 Sun H N, Zuo G F, Han D Q, et al. China Ceramics,2017,53(12),63(in Chinese).
孙海娜,左桂福,韩大庆,等.中国陶瓷,2017,53(12),63.