活性氧可激活的聚合物纳米载体用于光动力-化疗联合治疗的研究

doi:10.11896/cldb.19050040

Abstract
Figure/Table
References
Related Citation (2)

Download:

Full Text ( PDF ) (3209KB)

Suppl. Info.
Export: BibTeX | EndNote (RIS)

Abstract In tumor therapy, photodynamic therapy (PDT) has attracted more and more attention. In order to address the limitations of photosensitizer skin photosensitivity and molecular aggregation that can reduce photodynamic effects, the amphiphilic block copolymer containing reactive oxygen (ROS)-sensitive keto thiol-linked DOX was synthesized. The photosensitizer dihydroporphyrin e6 (Ce6) was physically encapsulated to construct the co-delivered nanocarrier which can be activated by intracellular ROS. The nanocarrier itself was in the inactive state, showing a weak photodynamic effect and low cytotoxicity. However, at high concentrations within the tumour cells under the action of ROS, ketone mercaptan linkage would be cleaved and DOX would be released, resulting in the disassembly of the micelles and release of Ce6. Ce6 and DOX could be released effectively in high ROS concentration. Compared to the nanocarriers that were not sensitive to intracellular ROS, the ROS sensitive nanocarriers could be readily activated after internalization. Therefore, more ROS could be generated after light irradiation. Moreover, the intracellular release of Ce6 and DOX was very beneficial to inhibit the proliferation of cancer cells. The co-delivered nanocarriers showed higher cytotoxic effect and inhibited the proliferation of cancer cells effectively compared with the single treatment of DOX and Ce6.

Key words： photodynamic therapy reactive oxygen nanocarriers combined therapy

Published: 26 April 2020

CLC number:

TQ050

Fund:This work was financially supported by National Natural Science Foundation of China (51573160).

Corresponding Authors: Qiao Jinis currently an associate professor in the Department of Polymer Science and Engineering at Zhejiang University. He received his Ph.D. in 2010 at Zhejiang University and worked as a postdoc follow at University of Marburg in Germany from 2011 to 2012. He joined Zhejiang University in 2012 and was appoin-ted as an associate professor since 2014. His main research interest focuses on stimuli-responsive polymers and smart drug delivery systems for cancer therapy. As first author or corresponding author, he has published more than 50 peer-reviewed papers, including ACS Nano, Material Horizons, Biomaterials, and Small.

About author:: Pengyu Song, male, born in April 1993 in Changzhou, Jiangsu province. In September 2011, he was admitted to the major of polymer materials and enginee-ring of School of Materials, Nanjing Tech University. In June 2015,he obtained the bachelor of engineering. From June 2015 to April 2016, worked as research and development assistant in Changzhou Huake Polymer CO., LTD. In September 2016, he was admitted to the department of polymer science and engineering of Zhejiang University to study for a master's degree in polymer materials.He is engaged in the research on the construction and application of photodynamic-chemotherapy combined treatment nanocarrier under the guidance of professor Qiao Jin.

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	SONG Pengyu
	DENG Yongyan
	HAN Haijie
	JIN Qiao

Cite this article:

SONG Pengyu,DENG Yongyan,HAN Haijie, et al. Reactive Oxygen Species Activated Polymeric Drug Nanocarriers for Combined Photodynamic-Chemotherapy of Cancer[J]. Materials Reports, 2020, 34(10): 10166-10170.

URL:

http://www.mater-rep.com/EN/10.11896/cldb.19050040 OR http://www.mater-rep.com/EN/Y2020/V34/I10/10166

1 Hu Z A, Xie Y L, Wang Y X, et al. Journal of Physical Chemistry C, 2009, 113(28),12502.
2 Bazarbashi S, Elbassiouni M, Abdelsalam M, et al. Journal of Surgical Oncology, 2010, 98(3),167.
3 Nicolescu N, Molnár G, Iancu C, et al. Chirurgia, 2011, 106(1),33.
4 Kortmann R D, Timmermann B, Taylor R E, et al. Strahlentherapie Und Onkologie, 2003, 179(9),585.
5 Kim J W, Jang J Y, Chang Y W. World Journal of Gastroenterology, 2015, 21(27),8358.
6 Agostinis P, Berg K, Cengel K A, et al. CA: A Cancer Journal for Clinicians, 2011,61(4),250.
7 Liu Y, Ban D X, Ma C, et al. Journal of Biomedical Nanotechnology, 2016, 12(11),2063.
8 Qin S Y, Zhang A Q, Zhang X Z. Small, 2018, 14(45), 1802417.
9 Chen D G,Xiong X Y,Gong Y C,et al.Material Reports A:Review Papers, 2019 33(2),517(in Chinese).
陈道鸽, 熊向源, 龚妍春, 等.材料导报:综述篇, 2019 33(2),517.
10 Jin Q, Deng Y, Chen X, et al. ACS Nano, 2019, 13, 954.
11 Wang Y, Deng Y, Luo H, et al. ACS Nano, 2017, 11(12), 12134.
12 Deng Y, Käfer F, Chen T, et al. Small, 2018, 14(37), 1802420.
13 Hartshorn C M, Bradbury M S, Lanza G M, et al. ACS Nano, 2017, 12(1),24.
14 Deng Y, Jia F, Chen S, et al. Biomaterials, 2018, 187, 55.
15 Wu J, Han H, Jin Q, et al. ACS Applied Materials & Interfaces, 2017, 9(17), 14596.
16 Du J Z, Li H J, Wang J. Accounts of Chemical Research, 2018, 51(11), 2848.
17 Lu A,Hou Y,Wu Z,et al. Acta Polymerica Sinica, 2016 (10), 1400(in Chinese).
陆爱菁, 侯宇, 吴正中, 等.高分子学报, 2016 (10), 1400.
18 Cao Z, Ma Y, Sun C, et al. Chemistry of Materials, 2018, 30(2),517.
19 Tong H, Chen Y, Li Z,et al. Small, 2016, 12(45),6223.
20 Han H, Valdepeérez D, Jin Q, et al. ACS Nano, 2017, 11(2),1281.
21 Elegbede A I, Banerjee J, Hanson A J, et al. Journal of the American Chemical Society, 2008, 130(32), 10633.
22 Kelley E G, Albert J N, Sullivan M O, et al. Chemical Society Reviews2013, 42, 7057.
23 Xiong M H, Bao Y, Du X J, et al. ACS Nano, 2013, 7(12),10636.
24 Lei Q, Wang S B, Hu J J, et al. ACS Nano, 2017, 11(7), 7201.
25 Wu J, Lin Y, Li H, et al. Journal of Colloid and Interface Science, 2017, 485, 251.
26 Li J, Sun C, Tao W, et al. Biomaterials, 2018, 170,147.
27 Hu J J, Lei Q, Peng M Y, et al. Biomaterials, 2017, 128, 136.