基于湿法球磨改性蒙脱土构建可负载疏水药物的海藻酸盐/有机蒙脱土复合凝胶微球及其释药性

doi:10.11896/cldb.19040208

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Abstract In order to construct a good organic hydrophobic drug carrier, the strong polarity and structural properties of montmorillonite were modified by wet ball-milling method using the nonionic surfactant, nonylphenolethoxylate (Np-10), as the modifier, to improve the montmorillonite's affi-nity for hydrophobic organic drug. Furthermore, the alginate/organic montmorillonite composite hydrogel bead (SA/OMMT HB) with slow and controlled release properties was prepared by the use of alginate as the coating material, under the exogenous cross-linking of calcium ions. The structure, properties and morphology of the prepared OMMT and SA/OMMT HB were characterized by FTIR, XRD, specific surface area and pore size analyzer, drug adsorption experiments, TGA and SEM. And the controlled release performance of the hydrophobic anti-inflammatory drug, ibuprofen, from SA/OMMT HB were also investigated. The experimental results showed that Np-10 was successfully inserted into the interlayer of Na-MMT under the action of wet ball-milling. The specific surface area of the modified OMMT increased from 67.69 m²/g to 208.31 m²/g. The results of the adsorption isotherm model fitting of ibuprofen by Na-MMT and OMMT showed that the affinity of OMMT for hydrophobic drugs was better than that of Na-MMT, which was more conductive to the loading of ibuprofen. In SA/OMMT HB, the OMMT sheet and alginate were combined by hydrogen bonding, which helped to improve the thermal stability of SA/OMMT HB. Moreover, the good affinity of OMMT to hydrophobic drug allowed SA/OMMT HB to exhibit good controlled release properties. According to the Peppas model equation fitting, the release process of ibuprofen from SA/OMMT HB belonged to the Non-Fickian diffusion mechanism, indicating that the drug itself diffuses and the swelling and degradation of the composite hydrogel beads jointly controlled the release rate of the drug.

Key words： alginate wet ball-milling organic montmorillonite composite hydrogel beads sustained release properties

Published: 26 April 2020

CLC number:

TQ235.5

Fund:This work was financially supported by the Natural Science Foundation of Hainan Province (218QN233), the Scientific Research Projects of Hainan Higher Education Institutions (Hnky2019-36), and the Innovation and Scientific Research Projects for Under-graduates of Hainan Normal University (cxcyxj2018001).

Corresponding Authors: Huiqiong Yanreceived his B. E. degree from Hainan University in 2010 and Ph. D. degree from Hainan Normal University in 2017. He is currently an associate professor in College of chemistry and chemical enginee-ring, Hainan Normal University. His research interests focus on the development and application of slow-release pesticide formulations, functional modification of seaweed polysaccharides, and preparation and application of tissue engineering scaffolds and biosensors based on alginate composite hydrogels. At present, he has published more than 60 journal papers, and applied for four national invention patents and three of them were authorized.

About author:: Chaoling Baoobtained her B. E.degree from Hainan Normal University in June 2018. Now studying at Hai-nan Normal University, a graduate student of Chemistry and Chemical Engineering College, mainly engaged in development and application of seaweed polysaccharide.

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	BAO Chaoling
	CHEN Xiuqiong
	LEI Mengyuan
	KE Chaoran
	ZHANG Wei
	YAN Huiqiong
	LIN Qiang

Cite this article:

BAO Chaoling,CHEN Xiuqiong,LEI Mengyuan, et al. Construction of Alginate/Organic Montmorillonite Composite Hydrogel Beads Capable of Loading Hydrophobic Drugs Based on Wet-ball Milling Method Modified Montmorillonite and Their Release Properties[J]. Materials Reports, 2020, 34(10): 10171-10176.

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http://www.mater-rep.com/EN/10.11896/cldb.19040208 OR http://www.mater-rep.com/EN/Y2020/V34/I10/10171

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