自愈合水凝胶的合成机理及生物医学应用

doi:10.11896/cldb.18070178

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Abstract Apolymer hydrogel is a soft material with high water content and generally composed of a polymer having a low degree of crosslinking. Hydrogels have been widely used in biomedical fields due to their advantages such as the structure and properties of hydrogels and the extremely high similarity of human soft tissues. Self-healing hydrogels are a new class of hydrogels that automatically restore their integrity and function after injury. Self-healing properties are important for extending the life of the material that is difficult to manufacture. To date, a variety of self-healing hydrogels have been synthesized by physical or dynamic chemical bonding. Physically crosslinked hydrogels are generally synthesized by multiple hydrogen bonding, host-guest interactions, ionic bonds, metal coordination, hydrophobic interactions, and supramolecular interactions. Chemical cross-linked self-healing hydrogels synthesized by dynamic chemical bonding have higher internal crosslink network strength than physical self-healing hydrogels, resulting in faster self-healing processes and higher mechanical strength. Therefore, dynamic chemical linkages such as imine bonds, hydrazide bonds and disulfide bonds, have been widely used to prepare self-healing hydrogels.
As a new intelligent material, self-healing hydrogel has a wide application prospect in the field of medical biology. However, most hydrogels are three-dimensional systems of hydrophilic cross-linking in response to external stimuli. In vivo, once external mechanical forces or physiological erosion disrupts the structural integrity of the hydrogel, the functionality of the hydrogel is lost. Thus, the structural and functional integrity of the hydrogel during use may be affected by external mechanical forces or chemical attack, particularly in complex in vivo environments. In order to solve this problem, self-healing hydrogel with intrinsic self-healing ability can overcome internal and external environmental destructive factors that has been designed and developed. With self-healing capabilities, hydrogels can repair their damage and restore their original structure and perfor-mance with or without external stimuli, improving reliability and safety. Compared with traditional hydrogels, self-healing hydrogels have a longer service life and higher mechanical properties, which makes self-healing hydrogels have broader application prospects, especially in three-dimensional cell culture, tissue engineering and drug delivery.
Since the research on self-healing hydrogels is still in its infancy, most of the research is still in the stage of exploring new self-healing hydrogel systems. In this review, the latest developments in self-healing hydrogels are highlighted, and the synthesis strategies of some self-healing hydrogels reported so far are summarized and analyzed, and the self-healing mechanism is described. Non-covalent bonds (physical bonds) include multiple hydrogen bonding, hydrophobic interactions, host-guest interactions, and dynamic covalent bonds (chemical bonds) include imine bonds and hydrazide bonds. In addition, the main factors affecting the self-healing properties of hydrogels and their extensive applications in biomedical fields such as tissue engineering and drug delivery were analyzed, which provide references for the preparation of novel self-healing hydrogels with superior performance.

Key words： hydrogel self-healing non-covalent bond dynamic covalent bond biomedical field

Published: 15 August 2019

CLC number:

O63

About author:: Jin Li graduated from Yantai University in June 2017 with a bachelor’s degree in engineering.Zinian Zhao is an associate professor at the School of Chemical Engineering and Materials, Tianjin University of Science and Technology, and a master’s tutor.Zhengzheng Li graduated from Chungnam National University in February 2014 with a doctor’s degree in engineering. She is currently an associate research fellow in the School of Chemical Engineering and Materials, Tianjin University of Science and Technology.

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	LI Jin
	ZHAO Zinian
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	XUE Song
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Cite this article:

LI Jin,ZHAO Zinian,LI Zhengzheng, et al. Synthetic Mechanism and Biomedical Application of Self-healing Hydrogel[J]. Materials Reports, 2019, 33(19): 3328-3335.

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http://www.mater-rep.com/EN/10.11896/cldb.18070178 OR http://www.mater-rep.com/EN/Y2019/V33/I19/3328

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