静电纺丝制备胶原基复合纳米医用纤维的研究进展

doi:10.11896/cldb.17110083

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Abstract Collagen with triple helix structure is considered to be a major component of the extracellular matrix, which is widely used in the field of biomedical materials due to its unique characteristics, including low immunogenicity and biodegradability. However, there are intramolecular, intermolecular hydrogen bonds, ionic bonds, van der Waals forces, and hydrophobic bonds between polar groups and non-polar groups inside the collagen, hence it can only be dissolved in limited range of solvents, such as dilute acetic acid, hexafluoroisopropanol and trifluoroethanol, ionic liquid, making it difficult to fabricate collagen nanofibers. Fluoroalcohol is the most commonly used solvent for collagen electrospinning, but it is also prone to destroy the triple helix structure of collagen to some extent. In addition, the lack of intermolecular and intramolecular crosslinking results in the unsatisfactory properties of collagen electrospun nanofibers, e.g. low mechanical strength and high degradation tendency.
In order to improve the performance of collagen nanofibers, researchers have invested considerable efforts in the co-electrospinning of collagen and organic polymer composites. The cooperation of the two materials significantly improves the strength of collagen nanofibers, meanwhile, endows them with other properties of organic polymers (elasticity, antibacterial, degradation resistance, etc.), which further extend their application in the biomedical field.
Natural polymers derived from animals and plants have good biocompatibility, and their natural biological structure is distinctive to synthetic polymers. Nevertheless, natural polymers are mostly polyelectrolytes, making it more difficult to synthesize compared to the synthetic polymers. The composite nanomedical fibers prepared by combining collagen with natural polymers can not only retain the biocompatibility of natural polymers, but also get improved in the mechanical properties of collagen electrospun membranes or obtain other functionalities. In this regard, the blending of collagen with silk fibroin, chitosan, elastin and hyaluronic acid has received major attention. Synthetic polymer has fine physical properties, certain biocompatibility, good processability, and excellent repeatability, thus it can be blended with collagen to improve the spinnability of collagen and the mechanical properties of fiber membranes. The obtained composite membranes were found to exhibit promising potential in the field of tissue engineering scaffolds and drug sustained release requiring long-term implantation. Commonly used synthetic polymers blended with collagen are polycaprolactone, polyethylene oxide, polyurethane, polylactic acid-glycolic acid copolymer, poly(L-lactic acid-co-ε-caprolactone), polyvinyl alcohol.
This review summarizes the global research status of collagen composite nanofibers fabricated by electrospinning method in recent years, focusing on the collagen/natural organic polymer composite nanofibers and the collagen/synthetic organic polymer composite nanofibers. It also provides an outlook over the future prospect.

Key words： collagen electropinning organic polymer nanofibers

Published: 15 August 2019

CLC number:

R318.08

About author:: Yanping Huang received her master’s degree in analytical chemistry from Sichuan University in 2016. She is currently pursing her Ph.D. at the College of Light Industry, Textile and Food Engineering, Sichuan University under the supervision of Prof. Weihua Dan is an expert who enjoys special government allowances of the State Council, received the academic and technical leaders of Sichuan Province and National Scientific and Technological Progress Award.

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	HUANG Yanping
	DAN Nianhua
	DAN Weihua

Cite this article:

HUANG Yanping,DAN Nianhua,DAN Weihua. Promising Biomedical Material Based on Collagen Composite ElectrospunNanofibers: a Review[J]. Materials Reports, 2019, 33(19): 3322-3327.

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http://www.mater-rep.com/EN/10.11896/cldb.17110083 OR http://www.mater-rep.com/EN/Y2019/V33/I19/3322

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